【摘要】：目的:探討術(shù)前血漿D-二聚體水平與漿液性卵巢癌一線化療療效及預(yù)后的相關(guān)性。方法:回顧性分析天津醫(yī)科大學(xué)腫瘤醫(yī)院2008年1月至2010年5月143例漿液性卵巢癌患者的術(shù)前血漿D-二聚體水平,并依據(jù)血漿D-二聚體正常水平分為血漿D-二聚體水平(≤0.3 mg/L)正常組(100例)和血漿D-二聚體水平(0.3 mg/L)升高組(43例),比較血漿D-二聚體不同水平與臨床病理因素、化療療效及預(yù)后的相關(guān)性。結(jié)果:血漿D-二聚體水平與FIGO分期、殘余病灶大小、惡性腹水、術(shù)前CA125水平及新輔助化療密切相關(guān)�；熀笱獫{D-二聚體水平升高組的完全緩解率34.88%(15/43)明顯低于血漿D-二聚體正常組73.00%(73/100),兩者比較差異具有統(tǒng)計(jì)學(xué)意義(P0.001)。血漿D-二聚體水平升高組的無進(jìn)展生存率與總生存率明顯低于血漿D-二聚體正常組(25.58%vs.50.00%與32.56%vs.65.00%),兩者比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。Cox多因素分析顯示血漿D-二聚體水平是患者預(yù)后的獨(dú)立預(yù)測因素。結(jié)論:術(shù)前血漿D-二聚體水平可作為有效預(yù)測漿液性卵巢癌一線化療療效及預(yù)后的生物學(xué)指標(biāo)。
[Abstract]:Objective: to investigate the correlation between plasma D-dimer level and first-line chemotherapeutic effect and prognosis of serous ovarian cancer. Methods: the plasma levels of D-dimer in 143 patients with serous ovarian cancer from January 2008 to May 2010 in Tianjin Medical University Oncology Hospital were retrospectively analyzed. According to the normal level of plasma D-dimer, the patients were divided into two groups: normal group (100 cases) with plasma D-dimer level (鈮，

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