【摘要】：繼2011年ACS(American Cancer Society,ACS)、ASCCP(American Society of Colposcopy and Cervica I Pathology,ASCCP)、ASCP(American Society of Clinical Pathology,ASCP)對(duì)宮頸癌及癌前病變篩查指南公布后,隨著幾項(xiàng)大型臨床研究數(shù)據(jù)的發(fā)表,支持hr HPV檢測(cè)用于初篩的證據(jù)越來(lái)越多。特別是在美國(guó)本土的一項(xiàng)前瞻性研究"滿足高級(jí)別HPV診斷需求(Addressing the Need for Advanced HPV Diagnostics,ATHENA)"試驗(yàn),揭示hr HPV檢測(cè)用于初篩在單輪篩查中對(duì)于CIN2、CIN3的敏感性優(yōu)于單獨(dú)細(xì)胞學(xué)篩查,并明確提出對(duì)hr HPV陽(yáng)性女性分流的策略。本文旨在對(duì)美國(guó)最新hr HPV檢測(cè)用于宮頸癌初篩指南的新建議及相關(guān)證據(jù)進(jìn)行介紹,同時(shí)提出對(duì)過(guò)渡期指南臨床應(yīng)用時(shí)帶來(lái)的問(wèn)題包括hr HPV取樣的質(zhì)量控制以及可能存在不同于HPV致癌的其他腫瘤發(fā)生途徑等臨床研究的必要性。
[Abstract]:Following the release of ACS (American Cancer Society,ACS), ASCCP (American Society of Colposcopy and Cervica I Pathology,ASCCP), ASCP (American Society of Clinical Pathology,ASCP guidelines for screening cervical cancer and precancerous lesions in 2011, with the publication of data from several large clinical studies, Evidence supporting hr HPV testing for primary screening is increasing. In particular, a prospective study in the United States, "meeting the High level HPV Diagnostic needs (Addressing the Need for Advanced HPV Diagnostics,ATHENA)" trial, revealed that hr HPV testing was more sensitive to CIN2,CIN3 than single cytological screening in a single round of screening. The strategy of shunt hr HPV positive women was put forward. The purpose of this paper is to introduce the new recommendations and relevant evidence of the latest hr HPV test for cervical cancer screening in the United States. At the same time, the problems arising from clinical application of transitional guidelines include the quality control of hr HPV sampling and the necessity of clinical research on the possible existence of other tumorigenesis pathways different from HPV carcinogenesis.
【作者單位】： 南京醫(yī)科大學(xué)第一臨床醫(yī)學(xué)院;南京醫(yī)科大學(xué)第一附屬醫(yī)院婦科;
【分類號(hào)】：R737.33

【共引文獻(xiàn)】

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9 魏葆s，

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