【摘要】：目的觀察補腎益氣和血法中藥對IVF-ET患者血清和卵泡液性激素水平的影響,探討補腎益氣和血法中藥對IVF-ET患者生殖內(nèi)分泌的作用。方法將自2016年4月~2017年1月在湖北省婦幼保健院生殖中心行IVF-ET的不孕婦女隨機分配為中藥組(51例)和對照組(48例)。對照組采用單純輔助生殖技術,中藥組在對照組方法上加用補腎益氣和血法中藥治療。比較兩組:(1)基礎(月經(jīng)第3天)和啟動日血清FSH、LH、E2、P、T、PRL水平,(2)HCG注射日血清LH、E2、P、T水平,(3)OPU日血清E2、P、T水平,(4)卵泡液中E2、P、T水平,(5)使用Gn的天數(shù)和Gn的總量。結(jié)果(1)啟動日,中藥組血清E2水平顯著低于對照組,兩組比較有顯著性差異(P=0.01),而FSH、LH、P、T、RPL無統(tǒng)計學差異(P0.05);(2)HCG注射日,中藥組血清E2水平顯著高于對照組,兩組比較有顯著性差異(P0.05),而LH、P、T兩組水平相當,無顯著性差異(P0.05);(3)OPU日,兩組血清E2、P中藥組顯者高于對照組,均有顯著性差異(P0.05),T兩組比較無顯著性差異(P0.05);(4)卵泡液E2、T兩組比較,中藥組明顯高于對照組,均有顯著性差異(均P0.05),兩組P比較無顯著性差異(P0.05);(5)兩組Gn用量和使用天數(shù)相比,中藥組Gn天數(shù)和Gn用量均小于對照組,有統(tǒng)計學差異(P0.01)。結(jié)論本研究提示,補腎益氣和血法中藥介入IVF-ET過程,可能影響血清和卵泡液中激素水平,可能降調(diào)啟動日血清E2水平,升調(diào)HCG日血清E2水平、OPU日血清E2和P水平以及卵泡液E2、T水平,增加卵泡對外源性Gn的敏感性。
[Abstract]:Objective to observe the effect of traditional Chinese medicine of tonifying kidney and supplementing qi and blood on the levels of sex hormones in serum and follicular fluid of patients with IVF-ET, and to explore the effect of traditional Chinese medicine of tonifying kidney and tonifying qi and blood on reproductive endocrine of patients with IVF-ET. Methods infertile women who received IVF-ET from April 2016 to January 2017 were randomly assigned to traditional Chinese medicine group (51 cases) and control group (48 cases). The control group was treated with simple assisted reproductive technique, while the control group was treated with traditional Chinese medicine of tonifying kidney and supplementing qi and blood. The serum FSH,LH,E2,P,T,PRL levels were compared between the two groups: (1) the serum FSH,LH,E2,P,T,PRL level on the 3rd day of menstruation, (2) the serum LH,E2,P,T level on the day of HCG injection, and (3) the serum E _ 2 ~ (2 +) P _ (+) T level on the day of OPU. (4) the level of E _ 2 ~ (2 +) P ~ (+) T in follicular fluid, (5) the days of using Gn and the total amount of Gn. Results (1) on the startup day, the serum E _ 2 level in the traditional Chinese medicine group was significantly lower than that in the control group, and there was a significant difference between the two groups (P0.01), but there was no significant difference in FSH,LH,P,T,RPL between the two groups (P0.05). (2) on the day of HCG injection, the serum E _ 2 level in the Chinese medicine group was significantly higher than that in the control group, and there was a significant difference between the two groups (P0.05), while the level of LH,P,T in the two groups was the same (P0.05). (3) on OPU day, the serum E2P of the two groups was significantly higher than that of the control group (P0.05). There was no significant difference between the two groups (P0.05). (4) compared with the control group, the Chinese medicine group was significantly higher than that of the control group (P0.05), but there was no significant difference between the two groups (P0.05). (5) compared with the two groups, the dosage of Gn and the dosage of Gn in the traditional Chinese medicine group were lower than those in the control group (P0.01). Conclusion this study suggests that the intervention of traditional Chinese medicine of tonifying kidney and tonifying qi and blood in the process of IVF-ET may affect the levels of hormones in serum and follicular fluid, decrease the level of serum E2 on the start day, and adjust the level of serum E2 on the day of ascending HCG. On the day of OPU, the levels of E _ 2 and P in serum and E _ 2 T in follicular fluid increased the sensitivity of follicle to exogenous Gn.
【學位授予單位】：湖北中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R714.8

【參考文獻】

相關期刊論文 前10條

1 宮潤蓮;;中藥周期療法治療慢性盆腔炎患者療效觀察[J];遼寧中醫(yī)藥大學學報;2017年05期

2 李新玲;張晉峰;梁峰艷;;補腎填精中藥對妊娠期小鼠子宮內(nèi)膜容受性影響的研究[J];世界中西醫(yī)結(jié)合雜志;2017年02期

3 郭麗娜;賈新轉(zhuǎn);呂翠婷;王楠;董翠;;高孕激素狀態(tài)下促排卵方案用于卵巢正常反應患者IVF-ET的自身對照研究[J];生殖醫(yī)學雜志;2017年02期

4 馬黔紅;;輔助生殖技術的新進展[J];中國計劃生育和婦產(chǎn)科;2017年01期

5 吳惠華;孟慶霞;鄒琴燕;李建芬;張艷;李紅;;長方案及拮抗劑方案中HCG日孕酮水平對IVF-ET妊娠結(jié)局的影響[J];生殖醫(yī)學雜志;2017年01期

6 喬宗惠;李道靜;龐麗娥;鮑蔓蔓;劉雨生;童先宏;吳麗敏;;人絨毛膜促性腺激素注射前血清孕激素升高的持續(xù)時間對體外受精-胚胎移植的影響[J];國際生殖健康/計劃生育雜志;2017年01期

7 劉世軍;唐志書;崔春利;劉紅波;梁艷妮;張娛;黨文濤;;中藥紅花化學成分的研究進展[J];河南中醫(yī);2017年01期

8 鐘鵬程;王良鑫;;溫腎活血方改善不孕癥患者子宮內(nèi)膜容受性臨床研究[J];亞太傳統(tǒng)醫(yī)藥;2017年01期

9 劉慧萍;曾柳庭;楊凱麟;張國民;;中藥復方對體外受精-胚胎移植干預治療的Meta分析和系統(tǒng)評價[J];生殖與避孕;2016年11期

10 張陽陽;鄶艷榮;王晟;薛晴;尚(青鳥);徐陽;;基礎雄激素及卵泡液雄激素水平與卵巢反應性及妊娠結(jié)局關系的探討[J];現(xiàn)代婦產(chǎn)科進展;2016年11期

相關碩士學位論文 前1條

1 仲躋高;菟絲子保護人精子凍存的初步研究[D];南京中醫(yī)藥大學;2007年

，

本文編號：2300015