【摘要】：目的觀察三伏貼治療妊娠期支氣管哮喘(妊娠哮喘)慢性持續(xù)期患者的臨床療效及可能作用機制。方法將100例妊娠哮喘慢性持續(xù)期患者隨機分為對照組和治療組各50例。對照組給予布地奈德氣霧劑吸入治療,每次256μg,每天1次,共30天。治療組在對照組的基礎上給予三伏貼治療,于頭伏、二伏、三伏的第1天各治療1次,末次貼敷10天后觀察兩組患者臨床療效、癥狀和體征緩解時間,檢測兩組患者治療前后肺功能、血清降鈣素(PCT)、25-羥維生素D3、血清C反應蛋白(CRP)水平及唾液中免疫球蛋白A(SIg A)、褪黑素和皮質(zhì)醇水平。結(jié)果治療后兩組患者血清PCT、CRP水平較治療前降低,25-羥維生素D3、SIg A、褪黑素和皮質(zhì)醇水平提高,肺功能改善,差異均有統(tǒng)計學意義(P0.05)。治療組治療后血清PCT和CRP較對照組明顯降低,25-羥維生素D3、SIg A、褪黑素和皮質(zhì)醇水平、肺功能明顯提高(P0.05)。治療組喘息、咳嗽、肺部哮鳴音、胸膈滿悶緩解時間明顯短于對照組(P0.05)。治療組臨床療效總有效率91.49%,對照組為75.00%,治療組療效優(yōu)于對照組(P0.05)。結(jié)論三伏貼可能通過降低血清PCT、CRP水平,提高血清25-羥維生素D3和唾液中SIg A、褪黑素和皮質(zhì)醇水平使妊娠哮喘慢性持續(xù)期患者臨床癥狀得到有效控制。
[Abstract]:Objective to observe the clinical effect and possible mechanism of Sanfu plaster in the treatment of patients with pregnancy asthma. Methods 100 patients with chronic pregnancy asthma were randomly divided into two groups: control group (n = 50) and treatment group (n = 50). The control group was treated with budesonide aerosol inhalation, 256 渭 g, once a day for 30 days. The treatment group was treated with Sanfu paste on the basis of the control group, treated once on the first day of scalp, 2 volts and 3 volts, and 10 days after the last application, the clinical effects, symptoms and signs of the two groups were observed. Lung function, serum calcitonin (PCT), 25-hydroxyvitamin D3, serum C-reactive protein (CRP) and saliva immunoglobulin A (SIg A), melatonin and cortisol levels were measured before and after treatment. Results after treatment, the serum PCT,CRP level of the two groups was lower than that before treatment, the levels of 25-hydroxyvitamin D _ 3 sig _ A, melatonin and cortisol were increased, and the lung function was improved, there was significant difference between the two groups (P0.05). The levels of serum PCT and CRP in the treatment group were significantly lower than those in the control group. The levels of 25-hydroxyvitamin D _ (3) sig A, melatonin and cortisol, and pulmonary function were significantly increased (P0.05). The time of relief of wheezing, cough, lung wheezing and fullness of chest and diaphragm in the treatment group was significantly shorter than that in the control group (P0.05). The total effective rate of the treatment group was 91.49 and that of the control group was 75.00. The curative effect of the treatment group was better than that of the control group (P0.05). Conclusion Sanfu paste can effectively control the clinical symptoms of patients with chronic pregnancy asthma by lowering the level of serum PCT,CRP and increasing the levels of serum 25-hydroxyvitamin D _ 3, SIg A, melatonin and cortisol in saliva.
【作者單位】： 河北聯(lián)合大學中醫(yī)學院;
【基金】：國家自然科學基金(81303046)
【分類號】：R714.253

【參考文獻】

相關期刊論文 前5條

1 沈世英;張光友;;三伏貼治療支氣管哮喘的臨床療效觀察[J];中國醫(yī)藥導刊;2013年07期

2 安玉珍;;150例患者應用冬病夏治三伏貼的護理[J];貴州醫(yī)藥;2014年04期

3 陳玉雯;吳少嬌;吉訓琦;陳實;馮小偉;;哮喘兒童血清25羥維生素D檢測及肺功能相關因素分析[J];海南醫(yī)學;2011年05期

4 中華醫(yī)學會呼吸病學分會哮喘學組;支氣管哮喘防治指南(支氣管哮喘的定義、診斷、治療及教育和管理方案)[J];中華結(jié)核和呼吸雜志;2003年03期

5 吳少卿;文道林;曹文平;;血清降鈣素原和C-反應蛋白在細菌感染性疾病診斷中的意義[J];中國現(xiàn)代醫(yī)藥雜志;2009年04期

【共引文獻】

相關期刊論文 前10條

1 楊程;彭波;童佳兵;王國俊;張四春;李澤庚;;肺氣虛證和肺陰虛證患者細胞因子變化的研究[J];中醫(yī)藥臨床雜志;2012年04期

2 趙世光;榮光生;仇煜;;支氣管舒張試驗的臨床應用評價[J];安徽衛(wèi)生職業(yè)技術學院學報;2010年02期

3 許海棠;余啟梅;吳祖鳳;李秀;;支氣管舒張試驗對肺通氣功能正常的疑似哮喘患者應用的意義[J];安徽醫(yī)學;2009年11期

4 饒會林;陳慶;方浩徽;陳文化;陳根旺;王菁;李志禮;楊建安;闞曉宏;;安徽省部分經(jīng)濟欠發(fā)達農(nóng)村地區(qū)哮喘控制實施情況分析[J];安徽醫(yī)學;2011年12期

5 張克昌;李維春;;支氣管哮喘患兒體內(nèi)嗜酸性粒細胞及IL-13TGF-β_1的檢測[J];安徽醫(yī)學;2011年12期

6 李紹修,項秀雯,安維哨,陳紹奉;基層醫(yī)院咳嗽變異性哮喘常用診斷方法的比較[J];安徽醫(yī)藥;2004年02期

7 張秀梅;湯懿珍;;白三烯受體拮抗劑曲尼司特治療哮喘的效果觀察及護理[J];安徽醫(yī)藥;2007年08期

8 金炬;;脈沖振蕩法結(jié)合舒張試驗在支氣管哮喘與慢性阻塞性肺疾病鑒別診斷中的應用[J];安徽醫(yī)藥;2008年08期

9 楊玲;;信必可都保聯(lián)合孟魯司特治療咳嗽變異性哮喘患者的療效觀察[J];安徽醫(yī)藥;2010年11期

10 羊禮榮;曹桂紅;;阿奇霉素治療小兒支氣管哮喘療效觀察[J];安徽醫(yī)藥;2011年01期

相關會議論文 前10條

1 李平;許萍;劉曉靜;;哮喘患者肺功能指標與轉(zhuǎn)化生長因子β_1關系的研究[A];江西省中西醫(yī)結(jié)合學會呼吸病專業(yè)委員會首次學術會議論文集[C];2009年

2 趙吉平;譚程;張昶;;從肺腸論治針刺對支氣管哮喘患者AQLQ的影響[A];2011中國針灸學會年會論文集（摘要）[C];2011年

3 鄭勁平;;肺功能檢查流調(diào)相關問題淺析[A];呼吸與危重癥醫(yī)學（2010-2011）[C];2011年

4 王真;楊s，

本文編號：2298284