【摘要】：目的:探討妊娠期肝內(nèi)膽汁淤積癥(ICP)與妊娠期高膽汁酸血癥(HP)的差異。方法:選擇重慶醫(yī)科大學(xué)附屬第一醫(yī)院的ICP孕婦374例和HP孕婦82例,并選擇同期分娩正常孕婦300例作為對(duì)照組。對(duì)其產(chǎn)前各項(xiàng)生化檢測(cè)指標(biāo)和妊娠結(jié)局進(jìn)行回顧性分析。結(jié)果:(1)ICP孕婦與正常孕婦比較,其剖宮產(chǎn)率、早產(chǎn)率和羊水糞染率的差異有統(tǒng)計(jì)學(xué)意義(P0.01)。HP孕婦組的剖宮產(chǎn)率和羊水糞染率明顯高于正常孕婦組(P0.05)。但HP孕婦組的剖宮產(chǎn)率和早產(chǎn)率顯著低于ICP孕婦組。(2)HP孕婦血清TBA水平與其妊娠結(jié)局無明顯相關(guān)性。(3)當(dāng)孕婦TBA≥40μmol/L時(shí),ICP孕婦的剖宮產(chǎn)、早產(chǎn)和羊水糞染的發(fā)生率顯著高于孕婦血清TBA在10-40μmol/L者(P0.05)。(4)黃疸型的ICP孕婦的早產(chǎn)率和羊水糞染率顯著高于無黃疸型ICP孕婦(P0.05)。(5)ICP孕婦血清ALT≥250U/L者早產(chǎn)發(fā)生率顯著高于ALT250U/L者(P0.05)。結(jié)論:妊娠期肝內(nèi)膽汁淤積癥與妊娠期高膽汁酸血癥是不同的,妊娠期高膽汁酸血癥母兒預(yù)后較好。妊娠期肝內(nèi)膽汁淤積癥病情嚴(yán)重程度與母體血清總膽汁酸、膽紅素和轉(zhuǎn)氨酶水平相關(guān)。
[Abstract]:Objective: to investigate the difference between (ICP) and (HP) in intrahepatic cholestasis of pregnancy. Methods: 374 ICP pregnant women and 82 HP pregnant women were selected from the first affiliated Hospital of Chongqing Medical University, and 300 normal pregnant women were selected as the control group. The antepartum biochemical indexes and pregnancy outcome were analyzed retrospectively. Results: (1) the cesarean section rate, premature delivery rate and amniotic fluid fecal staining rate of ICP pregnant women were significantly higher than those of normal pregnant women (P0.05). However, the rate of cesarean section and premature delivery in HP group was significantly lower than that in ICP group. (2) there was no significant correlation between the serum TBA level of pregnant women with HP and their pregnancy outcome. (3) when TBA 鈮，

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