【摘要】：目的探討超聲聯(lián)合腫瘤標(biāo)志物CA125對卵巢原發(fā)性惡性腫瘤的診斷效果。 方法將2010年1月至2012年12月于唐山市婦幼保健院就診，臨床懷疑有卵巢包塊的女性患者245例作為研究對象。術(shù)前均進(jìn)行腫瘤二維超聲、彩色多普勒超聲及三維超聲檢查及腫瘤標(biāo)志物CA125檢測，以術(shù)后腫物病理診斷為金標(biāo)準(zhǔn)，分析單純超聲、CA125及其聯(lián)合試驗(yàn)診斷卵巢惡性腫瘤的真實(shí)性、可靠性及其與病理結(jié)果的一致性，評價超聲與CA125聯(lián)合試驗(yàn)的診斷效果。 結(jié)果245例腫物進(jìn)行病理診斷后，共診斷出良性腫瘤160例，惡性腫瘤85例，良、惡性腫瘤在二維超聲中的形態(tài)、包膜、內(nèi)部結(jié)構(gòu)及實(shí)性回聲圖像不同，超聲檢查對卵巢原發(fā)性腫瘤的檢查其靈敏度為89.41%、特異度為85.00%、準(zhǔn)確度為86.53%、陽性預(yù)測值76%、陰性預(yù)測值93.79%、陽性似然比5.96、陰性似然比0.12，kappa值=0.72；腫瘤標(biāo)志物CA125對卵巢原發(fā)性腫瘤的檢查其靈敏度為88.24%、特異度為73.75%、準(zhǔn)確度為78.78%、陽性預(yù)測值64.10%、陰性預(yù)測值92.19%、陽性似然比3.36、陰性似然比0.16，kappa值=0.59；超聲結(jié)合腫瘤標(biāo)志物CA125其對卵巢原發(fā)性腫瘤的檢查靈敏度為95.29%、特異度為84.38%、準(zhǔn)確度為88.16%、陽性預(yù)測值76.42%、陰性預(yù)測值97.12%、陽性似然比6.10、陰性似然比0.06，kappa值=0.77。 結(jié)論單純的超聲檢查或腫瘤標(biāo)志物CA125檢查對卵巢原發(fā)性惡性腫瘤具有一定的診斷價值，，但靈敏度相對偏低，兩者聯(lián)合試驗(yàn)可以較大幅度提高診斷的靈敏度及一致性，提高臨床診斷效果。
[Abstract]:Objective to investigate the effect of ultrasound combined with tumor marker CA125 in diagnosis of primary ovarian malignant tumor. Methods from January 2010 to December 2012, 245 female patients with suspected ovarian mass were enrolled in the study. Two dimensional ultrasound, color Doppler ultrasound, three dimensional ultrasound and CA125 were performed before operation. The accuracy of simple ultrasound, CA125 and their combined tests in the diagnosis of ovarian malignant tumor was analyzed by using the pathological diagnosis of tumor as the gold standard. The reliability and consistency with pathological results were evaluated. The diagnostic effect of combined ultrasound and CA125 test was evaluated. Results after pathological diagnosis of 245 cases of tumor, 160 cases of benign tumor, 85 cases of malignant tumor, benign and malignant tumor were diagnosed. The morphology, capsule, internal structure and solid echo images of benign and malignant tumors were different in two-dimensional ultrasound. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio and negative likelihood ratio were 89.41, 85.00, 86.53, 76, 93.79, 5.96 and 0.12 kappa, respectively. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio and negative likelihood ratio of CA125 for primary ovarian tumors were 88.24, 73.75, 78.78, 64.10, 92.19, 3.36 and 0.59, respectively. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio and negative likelihood ratio of ultrasound combined with tumor marker CA125 for primary ovarian tumors were 95.29, 84.38, 88.16, 76.42, 97.12, 6.10 and 0.77, respectively. Conclusion simple ultrasound examination or tumor marker CA125 examination has certain diagnostic value for primary ovarian malignant tumor, but the sensitivity is relatively low. The combined test can greatly improve the sensitivity and consistency of diagnosis. To improve the clinical diagnosis effect.
【學(xué)位授予單位】：河北聯(lián)合大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R445.1;R737.31

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 唐軍;賴娟;耿京;呂君;;術(shù)前診斷卵巢交界性腫瘤的超聲特征[J];中國婦產(chǎn)科臨床雜志;2007年03期

2 汪宏波,王澤華,林美華;交界性和惡性卵巢上皮腫瘤微血管生成的研究[J];實(shí)用婦產(chǎn)科雜志;2000年06期

3 劉翔宇;王義成;溫德惠;馬姝穎;楊瑞敏;王欣業(yè);李朝喜;;e-flow在卵巢腫瘤診斷中的應(yīng)用[J];現(xiàn)代腫瘤醫(yī)學(xué);2012年06期

4 趙巧玲,李芬,王艷仙,常紅利,穆斐;超聲對卵巢惡性腫瘤的診斷價值[J];西安交通大學(xué)學(xué)報(醫(yī)學(xué)版);2003年01期

5 向紅,呂永泉,徐英,姚蘭輝,周春民,程進(jìn)新;經(jīng)陰道彩色多普勒能量顯像鑒別卵巢良惡性腫塊的價值[J];中國超聲醫(yī)學(xué)雜志;2000年01期

6 秦平,陳焰;二維超聲及彩色多普勒聯(lián)合應(yīng)用對卵巢腫瘤的診斷[J];中國超聲醫(yī)學(xué)雜志;2001年07期

7 趙玉珍,王月香,金瑞芳,紀(jì)曉惠,李英敏;卵巢腫瘤的三維彩色血管能量成像與病理微血管密度對比研究[J];中國超聲醫(yī)學(xué)雜志;2001年11期

8 王軍燕,汪龍霞,童新元,張晶,王東,冉淑芬;超聲在盆腔炎性腫塊與卵巢腫瘤鑒別診斷中的應(yīng)用[J];中國超聲醫(yī)學(xué)雜志;2003年07期

9 黃麗萍,唐少珊,劉守君,史鐵梅,蔡愛露;三維超聲成像在附件實(shí)性及囊實(shí)混合性腫塊中的應(yīng)用[J];中國超聲醫(yī)學(xué)雜志;2003年08期

10 白敏,陳惠莉,杜聯(lián)芳,許小云;乳腺癌57例超聲圖像分析[J];中國超聲醫(yī)學(xué)雜志;2004年12期

本文編號：2293939