【摘要】：目的:探討載藥納米粒聯(lián)合光動力治療應(yīng)用于大鼠卵巢癌腹水瘤模型治療的療效。方法:制備包裹竹紅菌乙素(HB)的聚氰基丙烯酸丁酯納米粒(PBCA-NP)及建立Fischer 344大鼠卵巢癌腹水瘤模型。大鼠腹腔注射HB的DMSO溶液及HB-PBCA-NP溶液,觀察不同藥物劑型在大鼠體內(nèi)分布,得到竹紅菌乙素及竹紅菌乙素納米粒的藥物動力學(xué)參數(shù)。將荷瘤大鼠隨機分成4組:對照組未給予任何處理,手術(shù)組只接受手術(shù)治療,實驗組分別給予HB溶液及其納米粒溶液,并接受手術(shù)及光動力治療,觀察生存時間。結(jié)果:納米粒穩(wěn)定,可用于體內(nèi)實驗。血清及腫瘤組織中,納米粒組藥物濃度達高峰的時間明顯延遲。手術(shù)聯(lián)合光動力治療中位生存時間(95天和99天)比單純手術(shù)(84天)長,可延長生存時間(P0.05)。結(jié)論:納米�？墒顾幬镌隗w內(nèi)達到緩釋,手術(shù)聯(lián)合光動力治療可延長生存時間。
[Abstract]:Objective: to investigate the therapeutic effect of drug loaded nanoparticles combined with photodynamic therapy on rat ovarian cancer ascites tumor model. Methods: Poly (butyl cyanoacrylate) nanoparticles (PBCA-NP) coated with (HB) were prepared and the ascites tumor model of ovarian cancer was established in Fischer 344 rats. Rats were injected intraperitoneally with DMSO solution and HB-PBCA-NP solution of HB. The pharmacokinetic parameters were obtained by observing the distribution of different drug formulations in rats. The rats were randomly divided into four groups: the control group did not receive any treatment, the operation group only received surgical treatment, the experimental group were given HB solution and nanoparticles solution, and received surgery and photodynamic therapy, and the survival time was observed. Results: the nanoparticles were stable and could be used for in vivo experiments. In serum and tumor tissue, the peak time of drug concentration in nanoparticles group was significantly delayed. The median survival time of operation combined with photodynamic therapy (95 days and 99 days) was longer than that of simple operation (84 days), and the survival time could be prolonged (P0.05). Conclusion: nanoparticles can make drug release in vivo, surgery combined with photodynamic therapy can prolong survival time.
【作者單位】： 山東大學(xué)齊魯醫(yī)院婦產(chǎn)科;
【基金】：國家自然科學(xué)基金資助項目(No:81172488;No:30700897)
【分類號】：R737.31

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