【摘要】：目的探討孕激素核受體A、B亞型(PR-A、PR-B)在卵巢漿液性囊腺癌(ovarian serous cystadenocarcinoma,OSC)發(fā)生、發(fā)展中的作用。方法采用免疫組化Eli Vision法檢測(cè)52例OSC、22例卵巢交界性漿液性囊腺瘤(ovarian borderline serous cystadenoma,OBSC)、22例正常輸卵管傘端(umbrella of normal fallopian,UNF)中PR-A、PR-B的表達(dá)。結(jié)果 OSC、OBSC和UNF中的PR-A陽(yáng)性率分別為94.5%、94.5%、68.38%,三組相比差異有顯著性(P0.05);OSC、OBSC和UNF中的PR-B陽(yáng)性率分別為100%、77.27%、40.38%,三組相比差異有顯著性(P0.05);三組中PR-A/PR-B的比值,差異有顯著性(P0.05)。PR-A、PR-B表達(dá)逐漸下降,Ⅰ+Ⅱ期與Ⅲ+Ⅳ期比較、Ⅰ級(jí)與Ⅱ級(jí)比較,差異有顯著性(P0.05);PR-A/PR-B比值在Ⅰ級(jí)與Ⅱ級(jí)組相比,差異有顯著性(P0.05);PR-B表達(dá)在OSC有、無(wú)淋巴結(jié)轉(zhuǎn)移組間差異有顯著性(P0.05)。PR-A、PR-B在OSC組織中表達(dá)呈正相關(guān)(P0.05)。結(jié)論隨著OSC惡性變的發(fā)生、發(fā)展PR-A、PR-B表達(dá)逐漸下調(diào),其中PR-B下調(diào)更為明顯,可能是卵巢組織惡性變的標(biāo)志;PR-A/PR-B比值的增大可能預(yù)示卵巢癌分化越差;PR-B相對(duì)高表達(dá)有利于抑制OSC的淋巴結(jié)轉(zhuǎn)移。
[Abstract]:Objective to investigate the role of progesterone nuclear receptor (PR-A,PR-B) in the pathogenesis and development of ovarian serous cystadenocarcinoma (ovarian serous cystadenocarcinoma,OSC). Methods the expression of PR-A,PR-B in 52 cases of ovarian borderline serous cystadenoma (ovarian borderline serous cystadenoma,OBSC) and 22 cases of normal fallopian tube (umbrella of normal fallopian,UNF) was detected by immunohistochemical Eli Vision method. Results the positive rates of PR-A in OSC,OBSC and UNF were 94.5% and 94.55%, respectively, with significant difference among the three groups (P0.05), and the positive rates of PR-B in OSC,OBSC and UNF were 77.2740.38%, respectively. There was significant difference among the three groups (P0.05), the ratio of PR-A/PR-B in the three groups was decreased gradually (P0.05), the expression of PR-A,PR-B decreased gradually (P0.05). There was significant difference between 鈪，

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