【摘要】：目的:探討稽留流產(chǎn)的胚胎絨毛染色體異常與口服葉酸、年齡、胚胎孕周及流產(chǎn)次數(shù)的關(guān)系。方法:收集稽留流產(chǎn)的胚胎絨毛組織82例,采用新一代基因測(cè)序(NGS)技術(shù)檢測(cè)胚胎絨毛染色體,分析口服葉酸、年齡、胚胎孕周、流產(chǎn)次數(shù)與染色體異常的關(guān)系。結(jié)果:82例稽留流產(chǎn)的胚胎絨毛染色體中,46例(56.10%,46/82)異常,其中數(shù)目異常38例(82.61%,38/46),結(jié)構(gòu)異常8例(17.39%,8/46),三體發(fā)生率89.47%(34/38)。82例胚胎絨毛染色體中,排除胚胎孕周等因素對(duì)年齡的影響,選擇25~39歲孕婦的胚胎絨毛染色共74例,其中染色體異常率62.16%(46/74),35~39歲孕婦的染色體異常率(43.48%,20/46)高于30~34歲(23.91%,11/46)、25~30歲(32.61%,15/46),差異有統(tǒng)計(jì)學(xué)意義(P0.05),30~35歲孕婦的染色體異常率與25~30歲孕婦比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。82例胚胎絨毛染色體中,排除年齡等因素對(duì)胚胎孕周的影響,胚胎停育孕周8~12周共78例,染色體異常率55.13%(43/78),胚胎停育孕周≤8周的染色體異常率(58.14%,25/43)高于8~12周(41.86%,18/43),差異有統(tǒng)計(jì)學(xué)意義(P0.0167)。流產(chǎn)1~5次的染色體異常率與流產(chǎn)0次比較,口服葉酸與未口服葉酸比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:胚胎絨毛染色體異常是引起稽留流產(chǎn)的重要因素,稽留流產(chǎn)的胚胎絨毛染色體異常與年齡、胚胎孕周密切相關(guān),與是否口服葉酸、流產(chǎn)次數(shù)(0~5次)無(wú)顯著關(guān)系。
[Abstract]:Objective: to investigate the relationship between chromosomal abnormalities of embryo villi and oral folic acid, age, gestational weeks and times of abortion in missed abortion. Methods: 82 cases of embryo chorionic villi with missed abortion were collected. The chromosomes of embryo villi were detected by a new generation of gene sequencing (NGS) technique. The relationship between oral folic acid, age, gestational weeks, times of abortion and chromosomal abnormalities was analyzed. Results: of the 82 aborted embryos, 46 (56.1010 / 82) were abnormal in number (82.61 / 46), 8 (17.3939 / 8 / 46) in structure, 89.47% (34 / 38) in trisomy, 89.47% (34 / 38) in trisomy, the influence of gestational weeks on age was excluded from 82 cases of embryo chorionic chromosomes, among which 38 cases were abnormal in number (82.61%), 8 cases (17.39% / 46) were abnormal in structure, and 89.47% (34 / 38) in trisomy. A total of 74 cases of embryo villus staining were selected from 25 to 39 year old pregnant women. The chromosomal abnormality rate was 62.16% (46 / 74), and the chromosome abnormality rate was 43.48% / 20 / 46 in 35 and 39 years old, higher than that in 30 ~ 34 years old (23.91 / 11 / 46), 25 ~ 30 years old (32.61 / 15 / 46), the difference was statistically significant (P0.05). The difference was not statistically significant (P0.05). In 82 cases of embryo chorionic chromosomes, the influence of age and other factors on gestational weeks was not significant (P0.05). There were 78 cases of embryo stopping gestational week 812 weeks. The chromosomal abnormality rate was 55.13% (43 / 78). The chromosomal abnormality rate (58.14 / 25 / 43) at gestational age 鈮，

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