【摘要】：目的：癌肉瘤(carcino sarcomas,CS)又被命名為:惡性混合性中胚葉腫瘤，也稱(chēng)為惡性混合性苗勒氏管腫瘤、肉瘤樣癌，是由惡性間葉成分和惡性上皮成分組成的混合性腫瘤。它是一種罕見(jiàn)的高度惡性腫瘤，可發(fā)生于食管、乳腺、肝、喉、肺、腎、膀胱、前列腺等處。子宮癌肉瘤是女性生殖系統(tǒng)癌肉瘤中最為常見(jiàn)的類(lèi)型，在子宮體惡性腫瘤中約占2%~5%，在卵巢惡性腫瘤中占不到1%，發(fā)生于宮頸和輸卵管的癌肉瘤則更為罕見(jiàn)。有報(bào)道指出，癌肉瘤的預(yù)后一般較差，5年生存率在20%~30%之間，目前尚沒(méi)有統(tǒng)一、有效的治療方案，尋求更有效的治療方案是改善預(yù)后的關(guān)鍵。本課題分析了12例就診于河北醫(yī)科大學(xué)第二醫(yī)院婦科的生殖道癌肉瘤患者，旨在總結(jié)女性生殖道癌肉瘤的臨床特點(diǎn)、影像學(xué)特點(diǎn)、病理及免疫組化特點(diǎn)、治療方案、影響預(yù)后的相關(guān)因素，為女性生殖道癌肉瘤的早期診斷及改善預(yù)后提供參考。 方法：對(duì)2003--2013年于河北醫(yī)科大學(xué)第二醫(yī)院婦科診治生殖道癌肉瘤病人12例回顧性總結(jié)分析女性生殖道癌肉瘤的臨床特點(diǎn)、影像學(xué)特點(diǎn)、病理及免疫組化特點(diǎn)、治療方案、影響預(yù)后的相關(guān)因素。 結(jié)果：本組子宮癌肉瘤5例，，卵巢癌肉瘤7例，其中I期2例、II期2例、III期6例、IV期2例。死亡4例的生存期分別是4、5、10、25個(gè)月。8例存活的生存期分別是48、40、36、28、24、15、6、4個(gè)月。 結(jié)論：女性生殖道癌肉瘤是一種惡性程度極高、侵襲性極強(qiáng)的腫瘤，治療應(yīng)采取以根治性手術(shù)為主并結(jié)合輔助放、化療的綜合性、個(gè)體化治療，但其臨床進(jìn)展迅速，預(yù)后極差。
[Abstract]:Objective: carcinosarcoma (carcino sarcomas,CS) is also named as malignant mixed mesodermal tumor, also known as malignant mixed mullerian duct tumor. Sarcomatoid carcinoma is a mixed tumor composed of malignant mesenchymal components and malignant epithelial components. It is a rare, highly malignant tumor that can occur in the esophagus, mammary gland, liver, larynx, lung, kidney, bladder, prostate, etc. Uterine carcinosarcoma is the most common type in female reproductive system carcinosarcoma, accounting for about 2% of uterine body malignant tumors, less than 1 in ovarian malignant tumors, and more rare in cervix and fallopian tube carcinosarcoma. It has been reported that the prognosis of carcinosarcoma is generally poor. The 5-year survival rate is between 20% and 30%. There is no uniform and effective treatment plan. Seeking more effective treatment is the key to improve the prognosis. Twelve patients with genital tract carcinosarcoma in the second Hospital of Hebei Medical University were analyzed in this paper. The purpose of this study was to summarize the clinical, imaging, pathological and immunohistochemical features of female genital tract carcinosarcoma. The related prognostic factors provide reference for early diagnosis and improvement of prognosis of female genital tract carcinosarcoma. Methods: twelve cases of gynecological diagnosis and treatment of female genital tract carcinosarcoma from 2003 to 2013 in the second Hospital of Hebei Medical University were retrospectively analyzed. Factors related to prognosis. Results: there were 5 cases of uterine carcinosarcoma and 7 cases of ovarian cancer sarcoma, including 2 cases of stage I, 2 cases of II, 6 cases of III and 2 cases of IV. The survival time of 4 dead cases was 10 and 25 months, respectively, and the survival time of 8 patients was 48 ~ 4036 ~ 2824 ~ 15 ~ (15) months, respectively. Conclusion: female genital tract carcinosarcoma is a highly malignant and aggressive tumor. Radical surgery should be taken as the main treatment, combined with adjuvant radiotherapy and chemotherapy, individualized treatment, but its clinical progress is rapid and the prognosis is very poor.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R737.3

【引證文獻(xiàn)】

相關(guān)期刊論文 前1條

1 楊楠;陳鳳;趙越;張佳慧;付艷;;宮頸癌肉瘤1例并文獻(xiàn)復(fù)習(xí)[J];中國(guó)實(shí)驗(yàn)診斷學(xué);2016年04期

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