發(fā)布時(shí)間：2018-10-16 14:44

【摘要】：目的:探索不同促排卵方案用于治療多囊卵巢綜合癥(PCOS)所致不孕的臨床效果。方法:選取我院2011年1月至2013年12月診療的PCOS不孕癥患者198例,隨機(jī)分為A、B、C三組,分別為64例、68例、66例。A組給予克羅米芬(CC)治療;B組給予人絕經(jīng)期促性腺激素(HMG)治療;C組給予克羅米芬聯(lián)合人絕經(jīng)期促性腺激素治療。觀察比較三組患者的排卵率、妊娠率及雌二醇(E2)、卵泡期黃體生成素(LH)及血清睪酮(T)水平。結(jié)果:C組E2水平最高達(dá)到865.67±387.31pg/L,B組均低于A組與C組(tAB=3.271,tBC=3.913,P0.05;tAC=1.567,P0.05)。LH值:A組LH水平明顯低于B、C組,差異有統(tǒng)計(jì)學(xué)意義(tAB=2.312,tAC=2.710,P0.05)。T值:三組之間的T水平,差異不具有統(tǒng)計(jì)學(xué)意義(tAB=0.843,tAC=1.241,tBC=1.397,P0.05)。A組40個(gè)周期排卵率61.50%,妊娠率為15.6%;B組35個(gè)排卵周期排卵率69.5%,妊娠率為19.1%,C組35個(gè)排卵周期排卵率83.51%,妊娠率為30.3%。C組的排卵率均高于A、B組,差異具有統(tǒng)計(jì)學(xué)意義(χ2AC=5.231,χ2BC=4.561,P均0.05)。C組的妊娠率也要由于A、B兩組,差異有統(tǒng)計(jì)學(xué)意義(χ2AC=4.231,χ2BC=3.861,P均0.05)。結(jié)論:采用CC聯(lián)合HMG治療PCOS致不孕癥是一個(gè)有效促排卵方案,進(jìn)一步的研究仍需大樣本的臨床隨機(jī)對(duì)照實(shí)驗(yàn)的隨訪進(jìn)一步研究證實(shí)該方案的有效性和安全性。
[Abstract]:Objective: to explore the clinical effect of different ovulation promotion protocols in the treatment of infertility caused by polycystic ovary syndrome (PCOS). Methods: 198 patients with PCOS infertility diagnosed and treated in our hospital from January 2011 to December 2013 were randomly divided into three groups. Group A was treated with clomiphene (CC), group B with human menopausal gonadotropin (HMG) and group C with clomiphene combined with human menopausal gonadotropin. The ovulation rate, pregnancy rate, estradiol (E _ 2), luteinizing hormone (LH) and serum testosterone (T) levels in the three groups were observed and compared. Results: the highest level of E _ 2 in group C was 865.67 鹵387.31 PG / L, which was lower than that in group A and C (tAB=3.271,tBC=3.913,P0.05;tAC=1.567,P0.05). LH value: the level of LH in group A was significantly lower than that in group C). The difference was statistically significant (tAB=2.312,tAC=2.710,P0.05). T value: t level between three groups). There was no significant difference (tAB=0.843,tAC=1.241,tBC=1.397,P0.05). A group 40 cycles ovulation rate 61.50, pregnancy rate 15.6B group 35 ovulation cycle ovulation rate 69.5%, pregnancy rate 19.1C group 35 ovulation cycle ovulation rate 83.51%, pregnancy rate 30.30.C group ovulation rate were higher than AB group. The difference was statistically significant (蠂 ~ 2AC = 5.231, 蠂 ~ 2BC = 4.561P all 0.05). The pregnancy rate of the two groups was also significantly higher than that of the control group (蠂 ~ 2AC = 4.231, 蠂 ~ 2BC = 3.861P, P < 0.05), and the difference was also significant between the two groups (蠂 ~ 2AC = 4.231, 蠂 ~ 2BC = 3.861, P < 0.05). Conclusion: CC combined with HMG is an effective ovulation-promoting regimen for infertility induced by PCOS. Further study needs to be carried out in a large clinical randomized controlled trial to confirm the efficacy and safety of the protocol.
【作者單位】： 吉林大學(xué)第二醫(yī)院;
【分類(lèi)號(hào)】：R714.8

【參考文獻(xiàn)】

相關(guān)期刊論文 前5條

1 林金芳;;促排卵藥物及綜合應(yīng)用方案[J];實(shí)用婦產(chǎn)科雜志;2008年08期

2 林春蓮;;不同促排卵方案治療多囊卵巢綜合征不孕的療效分析[J];臨床和實(shí)驗(yàn)醫(yī)學(xué)雜志;2011年13期

3 徐永紅;張玲;史六梅;;三種促排卵方案的比較[J];蘇州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2012年05期

4 李昕,林金芳;肥胖型多囊卵巢綜合征患者臨床及內(nèi)分泌代謝特征的研究[J];中華醫(yī)學(xué)雜志;2005年46期

5 葉琳;陸琳;高燕;;PCOS患者三種促排卵方案的療效比較[J];醫(yī)學(xué)理論與實(shí)踐;2012年17期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陳蘋(píng)顏;;中成藥坤靈丸治療無(wú)排卵不孕50例療效觀察[J];中醫(yī)藥導(dǎo)報(bào);2009年12期

2 周焰;秦貴軍;;多囊卵巢綜合征臨床特征分析[J];醫(yī)藥論壇雜志;2008年05期

3 林秀英;馮麗華;;多囊卵巢綜合征病因?qū)W研究進(jìn)展[J];吉林醫(yī)學(xué);2008年12期

4 林秀峰;吳嘉齊;譚愛(ài)玲;馮國(guó)梅;;肥胖型多囊卵巢綜合征治療結(jié)果的生化指標(biāo)評(píng)價(jià)[J];吉林醫(yī)學(xué);2010年16期

5 華飛;莊琦;錢(qián)鳳娟;唐f，

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