發(fā)布時間：2018-10-12 19:31

【摘要】：目的探討薄型子宮內(nèi)膜合并甲狀腺功能減退不孕患者行輔助生育治療后的效果。方法 165例因新鮮周期內(nèi)膜≤7 mm而取消胚胎移植的不孕患者,在擬行凍融胚胎移植前,對游離甲狀腺素T4(FT4)正常、促甲狀腺激素(TSH)2.5 mIU/L的患者進行左旋甲狀腺素片干預(yù)治療。經(jīng)治療4~8周后,患者依據(jù)TSH水平分為A組(n=70),TSH2.5 mIU/L;B組(n=95),TSH≤2.5 mIU/L。所有患者均采用相同劑量激素替代方案準備子宮內(nèi)膜,分析子宮內(nèi)膜情況及輔助生育結(jié)局。結(jié)果 A組與B組相比,雖然子宮內(nèi)膜下血流數(shù)量和阻力指數(shù)(RI)組間無統(tǒng)計學(xué)差異(P0.05),但B組內(nèi)膜下血流數(shù)量的均值高于A組,RI均值低于A組。且B組的子宮內(nèi)膜厚度、臨床妊娠率顯著高于A組(P0.05),流產(chǎn)率顯著低于A組(P0.05)。結(jié)論薄型子宮內(nèi)膜合并TSH升高的不孕患者,給予干預(yù)至TSH2.5 mIU/L后,行輔助生育治療可改善這些患者的妊娠結(jié)局。
[Abstract]:Objective to investigate the effect of assisted fertility therapy in infertile patients with thin endometrium complicated with hypothyroidism. Methods 165 infertile patients whose fresh endometrium was less than 7 mm were treated with levothyroxine tablet before freeze-thawing embryo transfer. The free thyroxine T4 (FT4) was normal and the thyroid stimulating hormone (TSH) was 2.5 mIU/L. After 4 weeks of treatment, patients were divided into two groups according to TSH level: group A (n = 70) and group TSH2.5 mIU/L;B (n = 95), TSH 鈮，

本文編號：2267333