T淋巴細胞亞群在妊娠與復發(fā)性自然流產中作用及治療研究進展
發(fā)布時間:2018-10-08 09:02
【摘要】:正胚胎攜帶父方的MHC單元型,相對于母體猶如同種異體移植,母胎免疫耐受是妊娠建立與維持的前提,機體免疫系統(tǒng)在其中發(fā)揮著復雜而精細的調控作用。T淋巴細胞是機體免疫調節(jié)的主體,主要包括輔助性T淋巴細胞(Th cell)及調節(jié)性T淋巴細胞(Treg),在抵御外界病原體感染、維持機體內環(huán)境穩(wěn)定過程中發(fā)揮著重要作用。隨著生殖免疫學研究的不斷深入,已證實不同T淋巴細胞亞群在誘導
[Abstract]:Compared with the maternal allograft, the maternal and fetal immune tolerance is the prerequisite for the establishment and maintenance of pregnancy. The immune system plays a complex and delicate regulatory role. T lymphocytes are the main body of immune regulation, including helper T lymphocyte (Th cell) and regulatory T lymphocyte (Treg), to resist the infection of external pathogens. It plays an important role in maintaining the stability of the internal environment. With the development of reproductive immunology, it has been proved that different T lymphocyte subsets are induced by different T lymphocyte subsets.
【作者單位】: 山東省腫瘤醫(yī)院;山東省醫(yī)學科學院基礎醫(yī)學研究所腫瘤免疫與中藥免疫重點實驗室;
【基金】:國家自然科學基金項目(No.81373670) 山東省自主創(chuàng)新成果轉化專項(2013ZHZX2A0405) 山東省科技發(fā)展計劃項目(No.2012GSF11840) 山東省自然科學基金項目(No.ZR2010HQ066) 山東省計生委項目[No.[2014]814 山東省中管局項目(2013-216,2013-218] 濟南市科技明星計劃項目(濟科合字2012)
【分類號】:R714.21
[Abstract]:Compared with the maternal allograft, the maternal and fetal immune tolerance is the prerequisite for the establishment and maintenance of pregnancy. The immune system plays a complex and delicate regulatory role. T lymphocytes are the main body of immune regulation, including helper T lymphocyte (Th cell) and regulatory T lymphocyte (Treg), to resist the infection of external pathogens. It plays an important role in maintaining the stability of the internal environment. With the development of reproductive immunology, it has been proved that different T lymphocyte subsets are induced by different T lymphocyte subsets.
【作者單位】: 山東省腫瘤醫(yī)院;山東省醫(yī)學科學院基礎醫(yī)學研究所腫瘤免疫與中藥免疫重點實驗室;
【基金】:國家自然科學基金項目(No.81373670) 山東省自主創(chuàng)新成果轉化專項(2013ZHZX2A0405) 山東省科技發(fā)展計劃項目(No.2012GSF11840) 山東省自然科學基金項目(No.ZR2010HQ066) 山東省計生委項目[No.[2014]814 山東省中管局項目(2013-216,2013-218] 濟南市科技明星計劃項目(濟科合字2012)
【分類號】:R714.21
【參考文獻】
相關期刊論文 前10條
1 許園園;劉雨生;;原因不明性復發(fā)性流產患者主動免疫治療效果及調節(jié)性T細胞水平變化觀察[J];安徽醫(yī)學;2009年10期
2 曹穎平;張e,
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