四川地區(qū)HPV亞型及多重感染與宮頸癌前病變的關(guān)系初探
發(fā)布時間:2018-10-08 07:52
【摘要】:目的檢測四川地區(qū)HPV不同亞型及多重感染在不同宮頸病變中的感染情況,評價多重感染與宮頸癌前病變〔宮頸上皮內(nèi)瘤變(CIN)〕的關(guān)系。方法回顧分析2006年6月至2012年5月在我院門診就診的1 226例宮頸病變患者(均有病理活檢結(jié)果),采用PCR-反向點雜交法檢測HPV 23種亞型均為陽性結(jié)果,分為宮頸炎組、宮頸濕疣組、CINⅠ組、CINⅡ組、CINⅢ組進行分層分析。結(jié)果1宮頸炎組、宮頸濕疣組、CINⅠ組分別與CINⅡ、CINⅢ組相比較,低危型HPV構(gòu)成比增加(P0.01),高危型HPV構(gòu)成比降低(P0.05)。2宮頸濕疣組低危型HPV感染主要為HPV6、HPV11,其他4組主要為HPV42、HPV43。3高危型HPV感染前4位為HPV58、HPV16、HPV52、HPV18,宮頸炎組HPV16型的構(gòu)成比(11.0%)低于CINⅡ(20.3%)和CINⅢ組(20.2%)(P0.01),HPV58型的構(gòu)成比(15.9%)低于CINⅡ組(21.4%)(P0.05)。4宮頸濕疣組HPV多重感染率(68.8%)高于宮頸炎組(23.1%)、CINⅠ組(26.1%)、CINⅡ組(27.8%)、CINⅢ組(27.1%),差異均有統(tǒng)計學(xué)意義(P0.01);而后4組間差異沒有統(tǒng)計學(xué)意義(P0.05)。結(jié)論四川地區(qū)HPV病毒感染有一定的地域性特點,各種宮頸病變中低危型主要為HPV42、HPV43,高危型主要為HPV58、HPV16、HPV52、HPV18,病毒的多重感染似乎并不是導(dǎo)致宮頸病變進展的重要因素。
[Abstract]:Objective to detect the infection of different subtypes and multiple infections of HPV in different cervical lesions in Sichuan and to evaluate the relationship between multiple infections and (CIN) in cervical precancerous lesions (cervical intraepithelial neoplasia). Methods from June 2006 to May 2012, 1 226 patients with cervical lesions (all with pathological biopsy results) were retrospectively analyzed. All 23 subtypes of HPV were detected by PCR- reverse dot hybridization and divided into cervicitis group. The cervical condyloma group was divided into two groups: cin 鈪,
本文編號:2255998
[Abstract]:Objective to detect the infection of different subtypes and multiple infections of HPV in different cervical lesions in Sichuan and to evaluate the relationship between multiple infections and (CIN) in cervical precancerous lesions (cervical intraepithelial neoplasia). Methods from June 2006 to May 2012, 1 226 patients with cervical lesions (all with pathological biopsy results) were retrospectively analyzed. All 23 subtypes of HPV were detected by PCR- reverse dot hybridization and divided into cervicitis group. The cervical condyloma group was divided into two groups: cin 鈪,
本文編號:2255998
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