宮頸非典型鱗狀上皮細胞、人乳頭狀瘤病毒聯(lián)合宮頸多點活檢及宮頸管搔刮診斷老年宮頸疾病的價值
發(fā)布時間:2018-10-05 08:05
【摘要】:目的通過對宮頸細胞學檢查結果為非典型鱗狀上皮細胞(ASU-US)的中老年患者進行人乳頭狀瘤病毒(HPV)聯(lián)合宮頸多點活檢及宮頸管搔刮(ECC)檢查的診斷價值。方法系統(tǒng)性回顧分析≥55歲的262例宮頸ASCUS患者的液基細胞學、高危型HPV定量檢測(HC2-HPV DNA)、陰道鏡檢查和組織病理學檢查資料。結果組織病理學確診情況,良性病變177例(67.56%)、宮頸上皮內瘤變(CIN)Ⅰ38例(14.5%)、CINⅡ18例(6.87%)、CINⅢ23例(8.78%)和浸潤性癌6例(2.29%)。相應的HC2-HPV DNA陽性率分別為9.6%(17/177),55.26%(21/38),88.89%(16/18),95.45%(21/23)和100%(6/6)。ECC所得的組織病理學為高級別鱗狀上皮內病變(HSIL)6例,而對應患者活檢完整組織塊病理學結果分別為低級別鱗狀上皮內病變(LSIL)和良性病變。HPV陽性組≥CINⅡ的檢出率53.09%(44/81),陰性組為0(0/181),二者差異有統(tǒng)計學意義(P0.05)。結論宮頸細胞學檢查為ASC-US的患者中存在不小比例的HSIL(CINⅡ和CINⅢ),甚至浸潤性癌。陰道鏡下宮頸活檢+宮頸管搔術有助于診斷,防止漏診。對ASC-US患者及時進行HC2-HPV DNA檢測,可作為ASC-US患者的分流手段,并采取規(guī)范診療措施能有效地發(fā)現(xiàn)潛在的HSIL或浸潤性癌病變。
[Abstract]:Objective to evaluate the diagnostic value of human papillomavirus (HPV) (HPV) combined with cervical multipoint biopsy and cervix curettage (ECC) examination in elderly patients with atypical squamous epithelial cells (ASU-US). Methods the liquid-based cytology, high risk HPV quantitative examination (HC2-HPV DNA), colposcopy and histopathological examination) of 262 patients with cervical ASCUS (鈮,
本文編號:2252625
[Abstract]:Objective to evaluate the diagnostic value of human papillomavirus (HPV) (HPV) combined with cervical multipoint biopsy and cervix curettage (ECC) examination in elderly patients with atypical squamous epithelial cells (ASU-US). Methods the liquid-based cytology, high risk HPV quantitative examination (HC2-HPV DNA), colposcopy and histopathological examination) of 262 patients with cervical ASCUS (鈮,
本文編號:2252625
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