【摘要】：目的:研究外陰上皮內(nèi)非瘤樣病變與陰道微生態(tài)的關(guān)系,為外陰上皮內(nèi)非瘤樣病變的診療提供線索。方法:收集2012年1月-2017年2月于重慶醫(yī)科大學(xué)附屬第二醫(yī)院婦科門診就診,最終活檢確診為外陰上皮內(nèi)非瘤樣病變且有完整資料的患者1020例,回顧性分析其陰道微生態(tài)狀況。結(jié)果:陰道微生態(tài)正常者占12.4%(126/1020);陰道微生態(tài)失調(diào)者占87.6%(894/1020),其中能夠明確致病菌診斷者占35.3%(360/1020),其內(nèi)細(xì)菌性陰道病占15.2%(155/1020),外陰陰道假絲酵母菌病占12.2%(124/1020),需氧菌性陰道病占3.0%(31/1020),滴蟲性陰道炎占0.7%(7/1020),混合感染占4.2%(43/1020);以細(xì)菌性陰道病及外陰陰道假絲酵母菌病多見(jiàn),明顯高于其它陰道炎患者(P0.05);不能檢測(cè)出明確病原菌,但已存在微生態(tài)失調(diào)者占52.3%(534/1020)。結(jié)論:外陰上皮內(nèi)非瘤樣病變患者的陰道微生態(tài)大部分處于失調(diào)狀態(tài),陰道微生態(tài)失衡導(dǎo)致的陰道炎可能與外陰上皮內(nèi)非瘤樣病變的發(fā)病有關(guān)。
[Abstract]:Objective: to study the relationship between vulvar intraepithelial nonneoplastic lesions and vaginal microecology, and to provide clues for diagnosis and treatment of vulvar intraepithelial nonneoplastic lesions. Methods: from January 2012 to February 2017, 1020 patients with nonneoplastic lesions of vulva and complete data were collected from gynecological outpatient clinic of the second affiliated Hospital of Chongqing Medical University, and their vaginal microecology was analyzed retrospectively. Results: the percentage of normal vaginal microecology was 12.4% (126 / 1020), vaginal microecology disorder was 87.6% (894 / 1020), the diagnosis of pathogenic bacteria was 35.3% (360 / 1020), bacterial vaginosis was 15.2% (155R / 1020), vulvovaginal myceliasis was 12.2% (124r1020), aerobic vaginosis was 3.0% (31r1020), trichomonas vaginalis was 3.0% (31r1020). Sex vaginitis accounted for 0.7% (7 / 1020), mixed infections accounted for 4.2% (43 / 1020), bacterial vaginosis and vulvovaginal candidiasis were common. It was significantly higher than that in other vaginitis (P0.05), but 52.3% (534 / 1020) had microecological disorders. Conclusion: the vaginal microecology of patients with vulvar intraepithelial nonneoplastic lesions is mostly in a maladjusted state. Vaginitis caused by vaginal microecology imbalance may be related to the pathogenesis of vulvar intraepithelial non-tumor-like lesions.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R711.72

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