卵巢子宮內(nèi)膜異位囊腫患者外周血Th17、Treg比例變化及意義
[Abstract]:Objective to investigate the role of helper T cell 17 (Th17), regulatory T cell (Treg) ratio and its regulatory gene in the development of ovarian endometriosis cysts. Methods 90 cases of ovarian endometriosis cyst were selected as observation group and 90 cases of infertility caused by simple fallopian tube as control group. The ratio of Th17,Treg to CD4 T cells in peripheral blood of two groups was detected by flow cytometry, and Th17/Treg. was calculated. Detection of mononuclear receptor 緯 (ROR- 緯) mRNA, forkhead transcription factor 3 (Fox P3) mRNA. in eutopic endometrium, eutopic endometrium and eutopic endometrium by qRT-PCR assay Serum interleukin-17 (IL-17) IL-22 and IL-10, transforming growth factor 尾 (TGF- 尾) were detected by ELISA. Results the ratio of Th17 to CD4 T cells in the observation group was significantly higher than that in the control group (P < 0. 05). The relative expression of ROR- 緯 mRNA in ectopic endometrium in observation group was lower than that in eutopic endometrium of observation group and in eutopic endometrium of control group (P 0.05), and the relative expression of ROR- 緯 mRNA in eutopic endometrium in observation group was lower than that in eutopic endometrium of control group (P0.05); The relative expression of Fox P3 mRNA in eutopic endometrium of observation group was higher than that in eutopic endometrium of control group (P 0.05), and the relative expression of P3 mRNA in eutopic endometrium in observation group was higher than that in eutopic endometrium of control group (P0.05). The level of serum IL-17,IL-22 in the observation group was higher than that in the control group (P < 0. 05). Conclusion the imbalance of Th17/Treg ratio in peripheral blood of patients with ovarian endometriosis and the imbalance of Th17 / Treg ratio may promote the occurrence and development of ovarian endometriosis cysts by regulating the expression of transcription factors and cytokines downstream.
【作者單位】: 青海紅十字醫(yī)院;
【分類號(hào)】:R711.71
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