【摘要】：目的:探討體重指數(shù)(BMI)增加對女性下丘腦-垂體-卵巢軸驅(qū)動性的影響。方法:按BMI將患者分為對照組(18.5BMI22.9kg/m2,162例)、超重組(23.0BMI24.9kg/m2,112例)和肥胖組(BMI≥25.0kg/m2,122例),采取放射免疫法測定FSH、LH、E2基礎(chǔ)數(shù)值,比較3組患者的月經(jīng)周期變化。結(jié)果:(1)超重組患者的FSH、LH、E2基礎(chǔ)值分別為(6.32±1.71)m IU/ml、(4.21±1.64)m IU/ml、(123.96±49.81)pmol/ml,肥胖組分別為(5.97±1.48)m IU/ml、(3.97±1.69)m IU/ml、(112.46±43.3)pmol/ml,兩組均較對照組明顯減低(P0.05);(2)超重組與肥胖組患者的月經(jīng)紊亂比例分別為46.4%和55.7%,明顯高于對照組(17.9%)(P0.05);(3)超重組和肥胖組的FSH/LH比值分別為1.73±0.77、1.78±0.86,呈FSH與LH比值倒置狀態(tài)。結(jié)論:BMI增加的患者可能減慢下丘腦GnRH脈沖發(fā)生器,使H-P-O軸驅(qū)動減弱,繼發(fā)性引起垂體促性腺激素釋放減慢,導(dǎo)致卵泡發(fā)育遲緩、月經(jīng)周期延長、黃體功能不足、自然流產(chǎn)甚至不孕癥。
[Abstract]:Objective: to investigate the effect of increasing body mass index (BMI) on the axis drive of hypothalamus-pituitary-ovary in women. Methods: according to BMI, the patients were divided into three groups: control group (18.5BMI22.9kg/m2162), superrecombinant (23.0BMI24.9kg/m2112) and obese (BMI 鈮，

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