發(fā)布時間：2018-09-07 12:08

【摘要】：腹腔鏡卵巢打孔術(shù)目前已越來越多地應(yīng)用于氯米芬抵抗的多囊卵巢綜合征(PCOS)患者。腹腔鏡卵巢打孔術(shù)可誘導(dǎo)單卵泡排卵,沒有卵巢過度刺激綜合征以及多胎妊娠的風(fēng)險,獲益時間可持續(xù)長達(dá)9年。但腹腔鏡卵巢打孔術(shù)僅能使部分患者獲益,對于一部分對腹腔鏡卵巢打孔術(shù)不應(yīng)答的女性,建立適當(dāng)?shù)男g(shù)前預(yù)測指標(biāo)能有效避免不必要的手術(shù)治療�；谀壳暗淖C據(jù),氯米芬抵抗的PCOS患者腹腔鏡卵巢打孔術(shù)后不良生殖結(jié)局的可能預(yù)測指標(biāo)包括:低基礎(chǔ)LH水平、雄激素增多癥的生物標(biāo)志物(游離雄激素指數(shù)≥15,術(shù)前雄烯二酮水平4.1 mmol/L)、高基礎(chǔ)抗苗勒管激素水平、不孕時長3.5年、年齡35歲,其中一些指標(biāo)尚有爭議,需進(jìn)一步研究其與腹腔鏡卵巢打孔術(shù)后生殖結(jié)局的關(guān)系。
[Abstract]:Laparoscopic ovarian perforation has been increasingly used in clomiphene resistant polycystic ovary syndrome (PCOS) patients. Laparoscopic ovarian drilling can induce single follicle ovulation without the risk of ovarian hyperstimulation syndrome and multiple pregnancy. However, laparoscopic ovarian perforation can only benefit some patients. For some women who do not respond to laparoscopic ovarian perforation, the establishment of appropriate preoperative predictors can effectively avoid unnecessary surgical treatment. Based on current evidence, potential predictors of poor reproductive outcomes after laparoscopic ovarian perforation in clomiphene resistant PCOS patients include low basic LH levels. The biomarker of androgen hypertrophy (free androgen index 鈮，

本文編號：2228219