發(fā)布時(shí)間：2018-09-06 18:58

【摘要】：目的:探討PAX-2、β-catenin和HAND2蛋白在良性子宮內(nèi)膜、不典型增生子宮內(nèi)膜及高分化子宮內(nèi)膜樣腺癌中的表達(dá)水平及其在鑒別診斷中的作用。方法:收集19例單純性增生子宮內(nèi)膜、19例復(fù)雜性增生子宮內(nèi)膜、22例復(fù)雜性伴不典型性增生子宮內(nèi)膜和26例高分化子宮內(nèi)膜樣腺癌組織,采用免疫組織化學(xué)Envision法檢測(cè)PAX-2、β-catenin和HAND2蛋白的表達(dá)情況。另外收集12例增生期子宮內(nèi)膜組織作為對(duì)照。結(jié)果:PAX-2和HAND2蛋白在良性增生性子宮內(nèi)膜、不典型增生及子宮內(nèi)膜樣腺癌的陽(yáng)性表達(dá)率明顯下降(P0.05);但在不典型增生子宮內(nèi)膜與高分化子宮內(nèi)膜樣腺癌組織之間的異常表達(dá)率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。β-catenin在不同類(lèi)型子宮內(nèi)膜病變中的異常表達(dá)率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:PAX-2和HAND2異常表達(dá)可能是區(qū)別良性子宮內(nèi)膜增生與腫瘤性子宮內(nèi)膜增生的有用的標(biāo)志物。
[Abstract]:Objective: To investigate the expression of PAX-2, beta-catenin and HAND2 proteins in benign endometrium, atypical hyperplasia endometrium and well-differentiated endometrioid adenocarcinoma and their role in differential diagnosis. The expression of PAX-2, beta-catenin and HAND2 proteins in endometrium and 26 cases of well-differentiated endometrioid adenocarcinoma were detected by immunohistochemical Envision method. 12 cases of proliferative endometrial tissues were collected as control group. Results: PAX-2 and HAND2 proteins were positive in benign proliferative endometrium, atypical hyperplasia and endometrioid adenocarcinoma. There was no significant difference between atypical hyperplasia endometrium and differentiated endometrioid adenocarcinoma (P 0.05). There was no significant difference in the abnormal expression of beta-catenin between different types of endometrial lesions (P 0.05). Conclusion: The abnormal expression of PAX-2 and HAND2 may be related to the abnormal expression of PAX-2 and HAND2. It is a useful marker for distinguishing benign endometrial hyperplasia from neoplastic endometrial hyperplasia.
【作者單位】： 東南大學(xué)醫(yī)學(xué)院;東南大學(xué)附屬中大醫(yī)院病理科;
【分類(lèi)號(hào)】：R737.33
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本文編號(hào)：2227225