【摘要】：目的觀察溴吡斯的明聯(lián)合甲磺酸多沙唑嗪治療老年女性宮頸癌術(shù)后尿潴留的臨床療效及安全性。方法將52例老年女性宮頸癌術(shù)后尿潴留患者隨機分為對照組26例與試驗組26例,2組患者均給予常規(guī)物理刺激。對照組給予甲磺酸多沙唑嗪片4 mg,每日1次,口服;試驗組在對照組的基礎(chǔ)上給予溴吡斯的明片60 mg,每日3次,口服。2組患者均用藥7 d。治療后,比較2組患者的臨床療效、尿動力學(xué)水平及藥物不良反應(yīng)發(fā)生情況。結(jié)果治療后,試驗組的總有效率為92.31%(24/26例),對照組為65.38%(17/26例),差異有統(tǒng)計學(xué)意義(P0.05)。治療后,試驗組殘留尿量、膀胱最大容量、逼尿肌順應(yīng)性、最大尿流率、最大尿流率時逼尿肌壓力分別為(40.14±5.57)mL,(300.19±31.89)mL,(32.00±4.18)cm H_2O,(10.02±1.43)mL·s~(-1),(25.71±3.14)cm H_2O;對照組分別為(69.88±8.37)mL,(5.02±0.53)mL,(56.39±6.19)mL·cm H_2O~(-1),(17.89±2.34)mL·s~(-1),(33.41±4.02)cm H_2O,差異均有統(tǒng)計學(xué)意義(P0.05)。試驗組藥物不良反應(yīng)有惡心、嘔吐、腹瀉,藥物不良反應(yīng)發(fā)生率為15.38%(4/26例),對照組藥物不良反應(yīng)有惡心、嘔吐、腹瀉,藥物不良反應(yīng)發(fā)生率為11.54%(3/26例)。2組藥物不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論溴吡斯的明聯(lián)合甲磺酸多沙唑嗪治療老年女性宮頸癌術(shù)后尿潴留的臨床療效顯著,安全性較高。
[Abstract]:Objective to observe the clinical efficacy and safety of brompiridamine combined with doxazosin mesylate in the treatment of postoperative urinary retention in elderly women with cervical cancer. Methods 52 elderly women with postoperative urinary retention were randomly divided into control group (n = 26) and experimental group (n = 26). The control group was given doxazosin mesylate once a day for 4 mg, and the experimental group was given brompiridamine tablets 3 times a day for 60 mg, on the basis of the control group. After treatment, the clinical efficacy, urodynamic level and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rate was 92.31% (24 / 26 cases) in the experimental group and 65.38% (17 / 26 cases) in the control group. The difference was statistically significant (P0.05). 娌葷枟鍚，

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