【摘要】：目的:探討月經(jīng)期取卵在卵巢低儲(chǔ)備(diminished ovarian reserve,DOR)患者體外受精-胚胎移植(IVF-ET)中應(yīng)用的可行性。方法:回顧性分析70例DOR行IVF/卵胞質(zhì)單精子注射(ICSI)-ET治療的不孕癥患者的臨床資料,比較其73個(gè)月經(jīng)期取卵和270個(gè)非月經(jīng)期取卵的結(jié)局。若月經(jīng)2~4 d陰道超聲提示優(yōu)勢(shì)卵泡直徑≥14 mm且E2水平200 ng/L則行月經(jīng)期取卵,若無(wú)優(yōu)勢(shì)卵泡按常規(guī)促排卵方案行IVF/ICSI,觀察其臨床結(jié)局。結(jié)果:月經(jīng)期組獲卵數(shù)、成熟卵數(shù)和可用胚胎數(shù)分別為1.0±0.4個(gè)、0.8±0.4個(gè)、0(0,1)個(gè),非月經(jīng)期組分為1.6±1.2個(gè)、1.4±1.1個(gè)、1(0,1)個(gè),組間有統(tǒng)計(jì)學(xué)差異(P0.05)。月經(jīng)期組周期取消率為72.6%,顯著高于非月經(jīng)期組43.0%(P0.05)。月經(jīng)期組獲卵率、卵裂率、卵子利用率分別為83.1%、94.7%和34.5%,非月經(jīng)期組分別為70.6%、96.7%和51.7%,組間無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:盡管月經(jīng)期取卵的獲卵數(shù)、成熟卵數(shù)、可用胚胎數(shù)小于非月經(jīng)期取卵,但獲卵率、卵裂率和卵子利用率組間無(wú)統(tǒng)計(jì)學(xué)差異,為反復(fù)周期取消、高基礎(chǔ)雌激素的DOR不孕癥患者節(jié)約了治療時(shí)間,提供了新的方法。
[Abstract]:Objective: to investigate the feasibility of in vitro fertilization and embryo transfer (IVF-ET) in patients with low reserve (diminished ovarian reserve,DOR. Methods: the clinical data of 70 patients with infertility treated with IVF/ oocyte sperm injection (ICSI)-et in DOR were retrospectively analyzed, and the outcomes of 73 months oocyte extraction and 270 non-menstrual period oocytes were compared. If the dominant follicle diameter 鈮，

本文編號(hào)：2218801