發(fā)布時(shí)間：2018-08-24 11:36

【摘要】：目的比較體外受精-胚胎移植(ⅣF-ET)與胚胎植入前遺傳學(xué)診斷或胚胎植入前遺傳學(xué)篩查(PGD/PGS)周期中D5、D6囊胚形成情況及妊娠結(jié)局,同時(shí)探究D5、D6囊胚的發(fā)育潛能及兩種助孕方式的優(yōu)劣。方法回顧性分析行ⅣF-ET助孕的138個(gè)周期及PGD/PGS篩查助孕的148個(gè)周期,按移植胚胎的發(fā)育天數(shù)分為ⅣF-D5組、ⅣF-D6組、PGD/PGS-D5組和PGD/PGS-D6組,分析比較各組的一般情況、囊胚形成情況及凍融移植后的種植率、臨床妊娠率、流產(chǎn)率等。結(jié)果ⅣF-D5組與ⅣF-D6組相比、PGD/PGS-D5組與PGD/PGS-D6組相比,D5組囊胚形成率、優(yōu)質(zhì)胚胎率、種植率、臨床妊娠率均高于D6組(P0.05);PGD/PGS周期中D5組整倍體囊胚檢出率高于D6組(P0.05);ⅣF-D5組與PGD/PGS-D5組相比、ⅣF-D6組與PGD/PGS-D6組相比,兩組間的囊胚形成率、優(yōu)質(zhì)胚胎率、種植率及臨床妊娠率均差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論兩種助孕方式下凍融移植D5囊胚比D6囊胚可獲得較好的臨床妊娠結(jié)局;與ⅣF相比,PGD/PGS并未明顯改善患者的妊娠結(jié)局。
[Abstract]:Objective to compare the blastocyst formation and pregnancy outcome between in vitro fertilization-embryo transfer (F-ET) and pre-implantation genetic diagnosis or pre-implantation genetic screening (PGD/PGS) cycle. At the same time, the developmental potential of D _ 5 D _ 6 blastocyst and the advantages and disadvantages of two ways of assisting pregnancy were investigated. Methods 138 cycles of 鈪，

本文編號(hào)：2200703