【摘要】：子癇前期與孕產(chǎn)婦及其圍生期發(fā)病率和病死率的增加關(guān)系密切。孕產(chǎn)婦子癇前期發(fā)病風(fēng)險(xiǎn)的早期識(shí)別可以有效地加強(qiáng)其孕期管理。預(yù)測(cè)子癇前期的監(jiān)測(cè)方法包括臨床病史、體格檢查、實(shí)驗(yàn)室檢查和血流動(dòng)力學(xué)檢查。一般來(lái)說(shuō),孕早期預(yù)測(cè)子癇前期發(fā)展的特異度好于敏感度,如:體質(zhì)量指數(shù)(BMI)大于34 kg/m2、甲胎蛋白、纖連蛋白和子宮動(dòng)脈多普勒(雙側(cè))的特異度均超過(guò)90%。只有子宮動(dòng)脈阻力指數(shù)和結(jié)合指數(shù)的敏感度超過(guò)60%。尿激肽釋放酶等檢查項(xiàng)目,在不考慮特異度的情況下具有高達(dá)80%以上的敏感度,但是其臨床應(yīng)用需要進(jìn)一步的研究。目前,臨床實(shí)踐中子癇前期的預(yù)測(cè)多是幾項(xiàng)檢查指標(biāo)的聯(lián)合應(yīng)用,沒(méi)有一項(xiàng)檢查項(xiàng)目具有足夠的精確度可以獨(dú)立使用。
[Abstract]:Preeclampsia is closely related to the increase of morbidity and mortality of pregnant women and their perinatal period. Early identification of maternal preeclampsia risk can effectively strengthen their pregnancy management. Monitoring methods for predicting preeclampsia include clinical history, physical examination, laboratory and hemodynamic examination. In general, the specificity of early pregnancy in predicting preeclampsia is better than that of sensitivity. For example, the body mass index (BMI) is greater than 34 kg/m2, alpha fetoprotein, fibronectin and uterine artery Doppler (bilateral) are more than 90%. Only uterine artery resistance index and binding index were more sensitive than 60. Urinary kallikrein and other tests have a sensitivity of more than 80% without considering the specificity, but its clinical application needs further study. At present, the prediction of preeclampsia in clinical practice is mostly a combination of several examination indicators, none of which has enough accuracy to be used independently.
【作者單位】： 天津醫(yī)科大學(xué);天津市中心婦產(chǎn)科醫(yī)院;
【分類(lèi)號(hào)】：R714.244

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