【摘要】：目的探討血清糖類抗原(carbohydrate antigen,CA)125、CA19-9對卵巢交界性腫瘤(borderline ovarian tumor,BOT)及上皮性卵巢癌(epithelial ovarian cancer,EOC)的診斷價值。方法以術(shù)后組織病理為金標(biāo)準(zhǔn),180例卵巢上皮性腫瘤患者中60例BOT者為BOT組,120例EOC者為EOC組。比較2組患者血清CA125、CA19-9水平與其臨床病理特征。結(jié)果 EOC組血清CA125水平(361.75u/mL)高于BOT組(17.61u/mL)(P0.01),EOC組和BOT組血清CA19-9水平(10.20、10.26u/mL)比較差異無統(tǒng)計學(xué)意義(P0.05);CA125、CA19-9鑒別BOT、EOC的AUC分別是0.850(95%CI:0.794~0.907,P=0.000)、0.448(95%CI:0.363~0.533,P=0.078),當(dāng)CA125的cut-off值為51.21u/mL時,其敏感性、特異度、陽性預(yù)測值、陰性預(yù)測值、陽性似然比、陰性似然比分別為80%、80%、88.9%、66.7%、4.00、0.25,CA125鑒別BOT、EOC的準(zhǔn)確性為80%;漿液性EOC、漿液性腫瘤(包括BOT、EOC)的CA125陽性率(88.2%、73.0%)高于CA19-9(18.6%、17.7%)(P0.05);漿液性腫瘤的CA125陽性率(73.0%)高于黏液性腫瘤(30.8%),黏液性腫瘤的CA19-9陽性率(34.6%)高于漿液性腫瘤(17.7%)(P0.05)。結(jié)論當(dāng)CA12551.21u/mL,對EOC和BOT的鑒別診斷有重要價值,而CA19-9對其鑒別無意義。
[Abstract]:Objective to investigate the diagnostic value of serum carbohydrate antigen 125 (CA19-9) in the diagnosis of ovarian borderline tumor (borderline ovarian tumor bot) and epithelial ovarian cancer (epithelial ovarian cancer-EOC). Methods among 180 cases of ovarian epithelial tumor, 60 cases of BOT were BOT group and 120 cases of EOC group were EOC group. The serum CA125 and CA19-9 levels and their clinicopathological features were compared between the two groups. 緇撴灉 EOC緇勮娓匔A125姘村鉤(361.75u/mL)楂樹簬BOT緇，

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