【摘要】：目的比較早期復(fù)發(fā)性流產(chǎn)(RSA)患者及正常婦女血栓彈力圖參數(shù)的變化,為早期RSA診斷和治療提供有效的檢測指標。方法對62例RSA患者和72例正常生育期婦女進行孕前及孕后的血栓彈力圖(TEG)檢測,統(tǒng)計各組TEG參數(shù)及妊娠丟失率的差異。結(jié)果 RSA組與正常組相比,最大凝塊振幅(MA)顯著增高,差異有統(tǒng)計學(xué)意義(t=2.37,P0.05),其余指標兩組間差異無統(tǒng)計學(xué)意義(t值分別為1.62、1.16、1.64,P0.05)。早孕期,RSA治療組與正常組的血栓彈力圖各參數(shù)差異無統(tǒng)計學(xué)意義(t值分別為1.57、1.34、1.16、0.54,均P0.05)。RSA未治療組MA值均顯著高于正常組、RSA治療組(t值分別為2.65、3.21,均P0.05),且R值顯著降低(t值分別為2.21、2.37,均P0.05),其余參數(shù)每兩組之間比較無顯著性差異(t值0.45~1.57,均P0.05)。妊娠丟失率方面,正常組、RSA治療組及未治療組相比較,妊娠丟失率依次升高,兩組間比較差異有統(tǒng)計學(xué)意義(χ2值分別為5.33、26.89、6.12,均P0.05)。結(jié)論血栓彈力圖可在非妊娠時鑒別部分RSA的女性是否處在血栓前狀態(tài)。在這樣狀態(tài)下未經(jīng)治療的RSA再次妊娠流產(chǎn)的風(fēng)險增高。監(jiān)測TEG有助于指導(dǎo)RSA高�；颊咝锌寡“逯委煛�
[Abstract]:Objective to compare the changes of thromboelastogram parameters in (RSA) patients with early recurrent abortion and normal women, and to provide an effective index for the diagnosis and treatment of early RSA. Methods 62 cases of RSA and 72 cases of normal pregnant women were examined with thromboelastogram (TEG) before and after pregnancy. The TEG parameters and pregnancy loss rate of each group were analyzed. Results compared with the normal group, the maximum clot amplitude (MA) in the RSA group was significantly higher than that in the normal group (t = 2.37, P 0.05), but there was no significant difference between the other two groups (t = 1.62, 1.16, 1.64, P 0.05). There was no significant difference in the parameters of thromboelastogram between the RSA treatment group and the normal group (t = 1.57 鹵1.34, P < 0.05). The MA value of RSA untreated group was significantly higher than that of the normal group (t value was 2.65 鹵3.21, P0.05), and the R value was significantly lower (t value was significantly lower than that in the normal group (t value was 2.65 鹵3.21, respectively). The values were 2.21 and 2.37, respectively (P0.05), and there was no significant difference in the other parameters between the two groups (t value 0.45 鹵1.57, P0.05). The pregnancy loss rate in the normal group was significantly higher than that in the untreated group (蠂 ~ 2 = 5.33 鹵26.89, P 0.05), and the pregnancy loss rate was significantly higher in the normal group than that in the untreated group (蠂 ~ 2 = 5.33 鹵26.89, P < 0.05). Conclusion Thromboelastography can distinguish partial RSA women from prethrombotic status during non-pregnancy. Untreated RSA in this state increases the risk of repregnancy. Monitoring TEG is helpful to guide high-risk RSA patients with anti-platelet therapy.
【作者單位】： 萊西市人民醫(yī)院產(chǎn)科;濰坊市人民醫(yī)院;青島市市立醫(yī)院婦科;
【分類號】：R714.21

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