【摘要】：目的探討坤泰膠囊治療在體外受精-胚胎移植(in vitrofertilization-embryo transfer,IVF-ET)中卵巢低反應(yīng)(poor ovarian response,POR)患者的臨床效果。方法 90例均為2015年4月—2016年4月在山東省濰坊市人民醫(yī)院生殖醫(yī)學(xué)科就診的卵巢儲(chǔ)備功能減退(diminished ovarian reserve,DOR)的不孕癥患者。均采用常規(guī)微刺激方案,充分知情同意,根據(jù)是否同意用藥分觀(guān)察組(48例)和對(duì)照組(42例),觀(guān)察組進(jìn)入周期前1個(gè)月開(kāi)始口服坤泰膠囊;對(duì)照組直接進(jìn)入周期。觀(guān)察兩組患者年齡、不孕年限、體質(zhì)量指數(shù)(body mass index,BMI)、腎陰虛證候評(píng)分、基礎(chǔ)卵泡刺激素(basal follicle stimulating hormone,bFSH)、基礎(chǔ)促黃體生成素(basal luteinizing hormone,bLH)、基礎(chǔ)雌二醇(basal estradiol,bE2)、基礎(chǔ)竇卵泡數(shù)(antral follicle count,AFC)、抗苗勒管激素(anti-Müllerian hormone,AMH)水平;比較兩組IVF過(guò)程中促性腺激素(gonadotropin,Gn)應(yīng)用天數(shù)、Gn用量、人絨毛膜促性腺激素(human chorionic gonadotrophin,HCG)扳機(jī)日單個(gè)成熟卵泡(直徑≥14mm)的E2水平、獲卵數(shù)、可移植胚胎數(shù)、優(yōu)質(zhì)胚胎數(shù)。結(jié)果兩組Gn天數(shù)及Gn用量,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);觀(guān)察組HCG日單個(gè)成熟卵泡E2水平、獲卵數(shù)、可移植胚胎數(shù)較對(duì)照組高(P0.05);優(yōu)胚數(shù)亦呈上升趨勢(shì),但差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論坤泰膠囊能提高IVF-ET中POR患者HCG日單個(gè)成熟卵泡E2水平,增加獲卵數(shù)和可移植胚胎數(shù),有助于改善IVF結(jié)局。
[Abstract]:Objective to investigate the clinical effect of Kuntai capsule in the treatment of ovarian low response (poor ovarian response in vitrofertilization-embryo transfer IVF-et. Methods from April 2015 to April 2016, 90 infertile patients with decreased ovarian reserve function (diminished ovarian reserve DOR) were treated in Department of Reproductive Medicine, Weifang people's Hospital, Shandong Province. All patients were treated with routine microstimulation regimen with full informed consent. According to whether they agreed to the medication, the observation group (48 cases) and the control group (42 cases) were given Kuntai capsule one month before the period and the control group entered the cycle directly. Age, length of infertility, body mass index (body mass), kidney yin deficiency syndrome score were observed in both groups. The levels of basal follicle stimulating hormone (basal follicle stimulating), basic luteinizing hormone (basal luteinizing), basal estradiol (E 2), basic antral follicle count (antral follicle count AFC), anti-M 眉 llerian hormoney (anti-M 眉 llerian hormonein G n) were compared between the two groups, and the days of using gonadotropin Gn during IVF were compared between the two groups. Human chorionic gonadotrophin (human chorionic gonadotrophin) triggers the E2 level of single mature follicles (diameter 鈮，

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