【摘要】：目的探討卵巢漿黏液性癌(ovarian seromucinous carcinomas,OSMCs)的臨床病理特征、免疫表型、預(yù)后特點(diǎn),以及與卵巢胃腸型黏液性癌(ovarian gastrointestinal mucinous carcinomas,OGIMCs)的差異。方法采用免疫組化Eli Vision法檢測(cè)所有癌組織中CK7、CK20、CDX2、WT1、p53、ER、PR、和ARID1A的表達(dá),分析比較15例OSMCs和33例OGIMCs的臨床病理特點(diǎn)和預(yù)后。結(jié)果 OSMCs組平均年齡與OGIMCs組相比差異無(wú)顯著性(P0.05);按FIGO分期,OSMCs中Ⅱ~Ⅳ期所占的比例明顯高于OGIMCs組(P0.05);OSMCs患者中位生存時(shí)間明顯低于OGIMCs組(P0.05);兩組間5年生存率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。OSMCs組中子宮內(nèi)膜異位癥比例高于OGIMCs組(P0.05);OSMCs比OGIMCs更多見(jiàn)雙側(cè)卵巢累犯(P0.05);OSMCs平均腫瘤直徑小于OGIMCs組(P0.05)。OSMCs組織學(xué)形態(tài)和細(xì)胞學(xué)形態(tài)復(fù)雜多樣,但均可見(jiàn)典型的子宮頸管型黏液上皮癌和低級(jí)別漿液性癌區(qū)域;以乳頭狀結(jié)構(gòu)為主,還可見(jiàn)腺樣、微小腺樣分化,實(shí)性生長(zhǎng);部分病例見(jiàn)子宮內(nèi)膜樣癌分化。OSMCs比OGIMCs更多見(jiàn)破壞性浸潤(rùn)。OSMCs均表達(dá)CK7,不表達(dá)CDX2,ER(80.0%)和PR(66.7%)陽(yáng)性率均高于OGIMCs組(P0.05),而ARID1A陽(yáng)性率(40.0%)低于OGIMCs組(P0.05)。結(jié)論 OSMCs比OGIMCs組織細(xì)胞學(xué)形態(tài)更復(fù)雜多樣,以浸潤(rùn)性破壞為主,OSMCs可能與子宮內(nèi)膜異位癥密切相關(guān)。OSMCs與OGIMCs的組織細(xì)胞起源可能不同。OSMCs中ARID1A失活可能與ER和PR表達(dá)上調(diào)有關(guān)。OSMCs是一種比OGIMCs惡性程度更高、預(yù)后更差的腫瘤。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, prognosis of ovarian mucinous carcinoma (ovarian seromucinous) and its difference from (ovarian gastrointestinal mucinous carcinomastric carcinoma (OGIMCs). Methods Immunohistochemical Eli Vision method was used to detect the expression of CK7 Eli Vision and ARID1A in all cancer tissues. The clinicopathological features and prognosis of 15 cases of OSMCs and 33 cases of OGIMCs were compared. Results there was no significant difference in average age between OSMCs group and OGIMCs group (P0.05), and the proportion of stage 鈪，

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