【摘要】：目的探討流產(chǎn)經(jīng)歷和子宮肌瘤家族史對(duì)子宮肌瘤患病風(fēng)險(xiǎn)的影響,為預(yù)防子宮肌瘤提出建議。方法采用病例-對(duì)照研究方法,使用結(jié)構(gòu)式問卷調(diào)查的方式收集山東省城市和農(nóng)村的10個(gè)縣級(jí)單位20~65歲常住已婚已育女性的流產(chǎn)經(jīng)歷和子宮肌瘤家族史,同時(shí)收集其年齡、身高等信息。運(yùn)用Logistic回歸模型分析流產(chǎn)經(jīng)歷和子宮肌瘤家族史與子宮肌瘤的關(guān)系。應(yīng)用交互作用的相對(duì)超額風(fēng)險(xiǎn)(RERI)、歸因于交互作用的比例(AP)和協(xié)同指數(shù)(S)三個(gè)指標(biāo)評(píng)價(jià)流產(chǎn)史和子宮肌瘤家族史的相加交互作用。結(jié)果多因素非條件Logistic回歸模型結(jié)果顯示,流產(chǎn)史(OR=1.39,95%CI:1.06~1.80)和子宮肌瘤家族史(OR=2.07,95%CI:1.36~3.15)均為子宮肌瘤的危險(xiǎn)因素。流產(chǎn)史和子宮肌瘤家族史對(duì)子宮肌瘤患病風(fēng)險(xiǎn)存在相加交互作用(S=5.51,AP=0.59,RERI=2.14)。有子宮肌瘤家族史的研究對(duì)象,1次流產(chǎn)和2次以上流產(chǎn)經(jīng)歷其子宮肌瘤患病風(fēng)險(xiǎn)分別增加1.78倍和2.77倍,而無遺傳背景的研究對(duì)象中,流產(chǎn)經(jīng)歷對(duì)子宮肌瘤發(fā)病影響較小。結(jié)論有子宮肌瘤遺傳背景的敏感人群應(yīng)注意計(jì)劃懷孕,謹(jǐn)慎流產(chǎn)以降低患子宮肌瘤的風(fēng)險(xiǎn)。
[Abstract]:Objective to investigate the influence of abortion experience and family history of uterine leiomyoma on the risk of uterine leiomyoma. Methods A case-control study was conducted to collect the abortion experience and family history of uterine leiomyoma in 10 county units of Shandong Province, aged 20 to 65 years old, by means of structured questionnaire, and their ages were collected at the same time. Height, etc. Logistic regression model was used to analyze the relationship between abortion experience, family history of uterine leiomyoma and uterine leiomyoma. The relative excess risk of interaction (RERI),) was attributed to the proportion of interaction (AP) and the synergistic index (S) were used to evaluate the additive interaction between abortion history and family history of uterine leiomyoma. Results the multivariate conditional Logistic regression model showed that the history of abortion (OR1.39) and the family history of uterine leiomyoma (OR 2.0795 CI 1.363.15) were all risk factors of uterine leiomyoma. The history of abortion and the family history of uterine leiomyoma had an additive interaction on the risk of uterine leiomyoma (S5. 51A APN 0. 59 RERI 2. 14). The risk of uterine leiomyoma was increased by 1.78 times and 2.77 times respectively in the subjects with family history of uterine leiomyoma. Among the subjects with no genetic background, the incidence of uterine myoma was less affected by abortion experience. Conclusion the sensitive population with genetic background of uterine leiomyoma should pay attention to planning pregnancy and careful abortion in order to reduce the risk of uterine leiomyoma.
【作者單位】： 山東大學(xué)公共衛(wèi)生學(xué)院流行病與衛(wèi)生統(tǒng)計(jì)學(xué)系;
【分類號(hào)】：R737.33

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