【摘要】：目的探討子宮肌瘤及子宮肌層中轉(zhuǎn)化生長因子(TGF)-β3與纖維連接蛋白(FN)表達的變化及意義。方法子宮肌瘤患者196例,其中絕經(jīng)者96例,未絕經(jīng)者100例,將絕經(jīng)者根據(jù)肌瘤是否萎縮分成萎縮組40例及未萎縮組56例,采用免疫組化法檢測并對比患者肌瘤組織和肌壁組織TGF-β3和FN的表達,應(yīng)用放射免疫法檢測并比較不同萎縮情況絕經(jīng)患者的雌激素(E2)、孕激素(P)水平,分析絕經(jīng)患者TGF-β3和FN與E2、P水平的相關(guān)性。結(jié)果絕經(jīng)組肌瘤組織和肌壁組織TGF-β3評分均明顯低于未絕經(jīng)組肌瘤組織均明顯高于同組肌壁組織(P0.05)。絕經(jīng)組和未絕經(jīng)組肌瘤組織及肌壁組織FN評分相比差異無統(tǒng)計學(xué)意義(P0.05)。萎縮組和未萎縮組肌瘤組織及肌壁組織TGF-β3、FN評分差異無統(tǒng)計學(xué)意義(P0.05),但兩組肌瘤組織均明顯高于同組肌壁組織(P0.05)。未萎縮組E2、P水平均明顯高于萎縮組(P0.05)。依據(jù)Spearman法分析可知,絕經(jīng)患者TGF-β3與E2、P水平均呈正相關(guān)(r=0.769,0.688;P=0.042,0.033),而絕經(jīng)患者的FN與E2、P水平無關(guān)(r=0.106,0.211;P=0.228,0.159)。結(jié)論子宮肌瘤絕經(jīng)患者TGF-β3表達較子宮肌層更高,且與E2、P水平密切相關(guān),而FN無明顯變化,臨床可嘗試通過監(jiān)測TGF-β3水平以評估患者的疾病情況。
[Abstract]:Objective to investigate the expression of transforming growth factor (TGF)-尾 3 and fibronectin (FN) in uterine myoma and myometrium. Methods 196 patients with uterine leiomyoma were divided into atrophic group (n = 40) and unatrophic group (n = 56) according to the atrophy of leiomyoma, including 96 cases of menopause and 100 cases of unmenopause. The expressions of TGF- 尾 3 and FN in myoma and muscle wall were detected and compared by immunohistochemical method. The levels of estrogen (E2) and progesterone (P) in menopausal patients with different atrophy were detected and compared by radioimmunoassay. To analyze the correlation between TGF- 尾 3 and FN and E 2 P in menopausal patients. Results the score of TGF- 尾 3 in myoma tissue and muscle wall tissue in menopausal group was significantly lower than that in unmenopausal group (P0.05). There was no significant difference in FN score between menopausal group and unmenopausal group in myoma tissue and muscle wall tissue (P0.05). There was no significant difference in TGF- 尾 _ 3 FN score between the atrophy group and the non-atrophy group (P0.05), but the difference between the two groups was significantly higher than that in the same group (P0.05). The level of E 2 P in non atrophy group was significantly higher than that in non atrophy group (P 0.05). According to Spearman analysis, there was a positive correlation between TGF- 尾 _ 3 and E _ 2P levels in menopausal patients (r = 0.769 ~ 0.688), but there was no correlation between FN and E _ 2P level in postmenopausal patients (r = 0.106 ~ 0.211P ~ (0.2280.159). Conclusion the expression of TGF- 尾 3 in postmenopausal women with uterine leiomyoma is higher than that in myometrium and is closely related to the level of E2P, but FN has no obvious change.
【作者單位】： 齊齊哈爾醫(yī)學(xué)院附屬第三醫(yī)院婦一科;哈爾濱醫(yī)科大學(xué)附屬第二醫(yī)院婦產(chǎn)科;
【基金】：黑龍江省衛(wèi)生廳科研課題(No.2011-083)
【分類號】：R737.33

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