【摘要】：背景:卵巢儲備功能是指卵巢中卵子的質量以及可以用于生殖的卵母細胞的數(shù)量。近年來,社會環(huán)境的變化及女性自身條件的改變導致女性不孕趨勢逐年增長。據(jù)統(tǒng)計大約10%的不孕女性卵巢儲備功能下降。卵巢儲備功能的預測指標研究較多的包括卵泡刺激素及抗苗勒管激素。ABO血型系統(tǒng)是一種非常穩(wěn)定的遺傳標記,研究表明ABO血型與心血管疾病、胃癌、胰腺癌等疾病有關聯(lián)。近些年有研究探討ABO血型與卵巢儲備功能之間的關系,但并未達成共識。血型是否與卵巢儲備功能有關,哪種抗原是保護或危險因素,尚存在爭議。目的:本文首次進行Meta分析以闡明ABO血型與卵巢儲備功能之間的相關性。方法:檢索中英文電子數(shù)據(jù)庫,以“ABO blood group”、“ovarian reserve”、“血型”、“卵巢儲備”為主題詞加自由詞進行檢索,并手工搜索相關研究的參考文獻,沒有語言和國家的限制。主要分析研究結果是卵巢儲備功能下降的發(fā)生率,研究的效應量懫用比值比(OR)及95%可信區(qū)間(CI)評價。統(tǒng)計分析使用Review Manager 5.3版本,采用Q檢驗和I2分析研究間的異質性。當P≥0.1和I2≤50%被認為是沒有異質性的研究;P0.1和I250%的研究被認為有異質性。由于隨機效應模型相對較保守,使結果更傾向于安全,故采用隨機效應模型。通過敏感性分析評估每一項研究對整體分析的影響來尋找異質性來源。結果:最終Meta分析納入七篇橫斷面研究,來自四個國家涉及55113人,采用卵泡刺激素及抗苗勒管激素兩種檢測指標判定卵巢儲備功能。以卵泡刺激素測定卵巢儲備功能的五篇研究進行分析,結果顯示A型血OR=1.03(95%CI:0.96~1.11),I2=17%;B型血OR=0.98(95%CI:0.75~1.29),I2=88%;AB型血OR=0.96(95%CI:0.71~1.30),I2=75%;O型血OR=1.03(95%CI:0.74~1.43),I2=94%。以抗苗勒管激素測定卵巢儲備功能的兩篇研究進行分析,結果顯示A型血OR=0.89(95%CI:0.76~1.03),I2=0%;B型血OR=1.02(95%CI:0.80~1.30),I2=24%;AB型血OR=1.14(95%CI:0.80~1.64),I2=0%;O型血OR=1.07(95%CI:0.86~1.34),I2=46%。結論:以現(xiàn)有的研究未發(fā)現(xiàn)ABO血型與卵巢儲備功能之間的關聯(lián)。然而,需要更多、更嚴謹、高質量、大樣本和多指標的研究進行進一步的驗證。
[Abstract]:Background: ovarian reserve function refers to the quality of eggs in the ovary and the number of oocytes that can be used to reproduce. In recent years, the change of social environment and women's own conditions lead to the increasing trend of female infertility. According to statistics, about 10% of infertile women ovarian reserve function decline. The predictors of ovarian reserve function include follicle stimulating hormone (FSH) and anti-Mullerian hormone. ABO blood group system is a very stable genetic marker. It is shown that ABO blood group is associated with cardiovascular disease, gastric cancer, pancreatic cancer and other diseases. Recent studies have explored the relationship between ABO blood group and ovarian reserve function, but there is no consensus. Whether blood type is related to ovarian reserve function, which antigens are protective or risk factors remains controversial. Objective: to investigate the correlation between ABO blood group and ovarian reserve function by meta-analysis for the first time. Methods: Chinese and English electronic databases were searched with "ABO blood group", "ovarian reserve", "blood group" and "ovary reserve" as subject words plus free words. The main result of the study was the incidence of ovarian reserve function decline. The effect of the study was evaluated by ratio (OR) and 95% confidence interval (CI). Statistical analysis used Review Manager 5.3 version, Q test and I 2 analysis of heterogeneity. When P 鈮，

本文編號：2138798