【摘要】：目的觀察母代高脂飲食對F2代大鼠的不良代謝影響。方法 3周齡SD雌性大鼠隨機(jī)分為高脂飲食組(F0-HF組)和對照組(F0-CON組),至11周齡時(shí)交配懷孕產(chǎn)仔(F1代),母鼠按原飼養(yǎng)要求喂養(yǎng)至哺乳期結(jié)束。F1代大鼠斷乳后均予普通飼料喂養(yǎng)至11周齡時(shí)再次交配產(chǎn)仔(F2-HCC組和F2-CON組),兩組F2代大鼠均普通飼料喂養(yǎng)至3周齡,觀察其糖脂代謝相關(guān)指標(biāo)變化。結(jié)果 F2-HCC組大鼠出生、1周齡時(shí)體質(zhì)量明顯高于對照組大鼠,差異有統(tǒng)計(jì)學(xué)意義(P均0.05);F2-HCC組大鼠3周齡時(shí)空腹血糖和糖耐量曲線下面積均高于對照組,血清總膽固醇和肝臟三酰甘油水平均高于對照組,差異有統(tǒng)計(jì)學(xué)意義(P均0.05);1日齡及3周齡時(shí)F2-HCC組大鼠表現(xiàn)出不同程度的脂肪肝,對照組大鼠肝臟鏡下結(jié)構(gòu)均正常。結(jié)論母代高脂飲食可引起F2代大鼠體質(zhì)量增加、肝臟脂肪變性及糖耐量受損,后代發(fā)生代謝性疾病的危險(xiǎn)性增加。
[Abstract]:Objective to observe the effect of maternal high fat diet on adverse metabolism of F 2 rats. Methods three week-old SD female rats were randomly divided into high fat diet group (F0-HF group) and control group (F0-CON group). At the age of 11 weeks, the female rats were mated and pregnant (F1 generation). The female rats were fed in accordance with the original feeding requirements until the end of lactation. After feeding forage to 11 weeks of age, they were remated and born (F2-HCC group and F2-Con group). The F2 generation rats in both groups were fed with common diet until 3 weeks old. The related indexes of glucose and lipid metabolism were observed. Results the body mass of F2-HCC group was significantly higher than that of control group at 1 week old (P 0.05). The area under fasting blood glucose and glucose tolerance curve of F2-HCC group was higher than that of control group at 3 weeks old. The levels of serum total cholesterol and hepatic triglyceride were significantly higher than those of the control group (P 0.05). At the age of 1 day and 3 weeks, the F2-HCC rats showed fatty liver of different degrees, and the liver structure of the control group was normal under microscope. Conclusion Maternal high-fat diet can increase the body mass of F2 rats, liver steatosis and impaired glucose tolerance, and increase the risk of metabolic diseases in offspring.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬新華醫(yī)院內(nèi)分泌科;上海交通大學(xué)醫(yī)學(xué)院附屬新華醫(yī)院消化內(nèi)科;
【基金】：上海交通大學(xué)科技基金項(xiàng)目(No.11XJ21037)
【分類號】：R714.2

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