本文選題：醋酸亮丙瑞林 + 反加療法��； 參考：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:比較醋酸亮丙瑞林(LA)聯(lián)合反加不同劑量替勃龍對子宮內(nèi)膜異位癥(EM)患者內(nèi)分泌水平、血清骨鈣素(BGP)及骨密度(BMD)的影響。方法:選擇2014年3月至2015年3月于新疆醫(yī)科大學(xué)第一附屬醫(yī)院婦科三病區(qū)行腹腔鏡保守性手術(shù),病理結(jié)果證實為EM,術(shù)后使用LA治療的患者148例,隨機分為3組,A組48例,未反向添加任何藥物,僅口服鈣片。B組50例給予反加藥物替勃龍1.25mg/d,C組50例給與反加藥物替勃龍2.5mg/d,B、C組自第一次注射LA后給與反加藥物替勃龍,連續(xù)服用至療程結(jié)束。記錄治療前后兩組血雌二醇(E2)、卵泡刺激素(FSH)、促黃體生成素(LH)、BG P及BMD變化。并隨訪A、B、C3組停藥后6個月、12個月的BGP及MD變化情況。結(jié)果:3組患者治療前后測試女性激素結(jié)果顯示FS H、LH、E2明顯下降,前后比較具有統(tǒng)計學(xué)差異(P0.05);治療后各組間激素比較無統(tǒng)計學(xué)差異(P0.05);3組患者BGP值均比較結(jié)果顯示治療后均升高,其中A組患者治療前后比較具有統(tǒng)計學(xué)差異(P0.05);B、C兩組患者治療前后無統(tǒng)計學(xué)差異(P0.05);3組患者隨訪結(jié)果顯示A組患者24W治療后腰椎BMD低于治療前,前后比較具有統(tǒng)計學(xué)差異(P0.05),停藥后6個月及12個月后腰椎BMD值緩慢上升,兩次隨訪結(jié)果顯示與治療前相比差異具有統(tǒng)計性(P0.05);B、C兩組患者隨訪結(jié)果顯示腰椎骨密BMD低于治療前,二者比較無統(tǒng)計學(xué)差異(P0.05)。A、B、C3組股骨粗隆BMD在用藥24w后、停藥后6個月及12個月均未恢復(fù)至治療前,但較治療前比較差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:LA聯(lián)合替勃龍治療EM可減少骨質(zhì)丟失,且低劑量替勃龍可維持BMD。
[Abstract]:Objective: To compare the effects of light propane acetate (LA) combined with different doses of troneon on endocrine level, Serum Osteocalcin (BGP) and bone mineral density (BMD) in patients with endometriosis (EM). Methods: laparoscopic conservative surgery was performed in the First Affiliated Hospital of Xinjiang Medical University from March 2014 to March 2015 in the three Department of gynecologic department in the First Affiliated Hospital of Xinjiang Medical University. 148 patients with EM and LA after operation were randomly divided into 3 groups, 48 cases in group A, no reverse addition of any medicine, only 50 cases of the calcium tablet.B group were given the anti adding drug tren 1.25mg/d, and the group C was given the anti addition drug tren 2.5mg/d, B, and the C group from the first injection of LA after the first injection to the end of the course to the end of the course. Two groups of blood estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), BG P and BMD were observed before and after treatment. The changes of BGP and MD were followed up by A, B, and C3 group after 6 months, 12 months after treatment. There was no statistical difference between groups (P0.05). The results of BGP values in the 3 groups showed that all of the patients in the group A had a statistically significant difference (P0.05) before and after treatment (P0.05), and there was no statistical difference between before and after treatment in group A and C (P0.05). The follow-up results in the 3 group showed that the lumbar BMD was lower than before and before the treatment, before and after the 24W treatment in the group A. Compared with the statistical difference (P0.05), 6 months and 12 months after the withdrawal of the lumbar BMD value slowly increased, two follow-up results showed that the difference was statistically significant compared with before treatment (P0.05); B, C two patients follow-up results showed that the bone density of the lumbar spine was lower than before the treatment, the two had no statistical difference (P0.05).A, B, C3 group femur BMD in 24W drug 24W. After 6 months and 12 months after drug withdrawal, no significant difference was found before treatment, but there was no significant difference compared with before treatment (P0.05). Conclusion: LA combined with the treatment of EM can reduce bone loss, and low dose of trerone can maintain BMD.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R711.71

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