天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

中孕早期子癇前期聯(lián)合預(yù)測(cè)指標(biāo)的價(jià)值

發(fā)布時(shí)間:2018-07-10 00:06

  本文選題:子癇前期 + 平均動(dòng)脈壓 ; 參考:《中國婦產(chǎn)科臨床雜志》2017年03期


【摘要】:目的探討中孕早期聯(lián)合母體特征、平均動(dòng)脈壓(MAP)及血清學(xué)標(biāo)記物預(yù)測(cè)子癇前期(PE)的價(jià)值。方法前瞻性留取2014年5月至2015年5月孕婦行中期唐氏篩查時(shí)的血樣,追蹤妊娠結(jié)局,獲取重癥子癇前期(SPE)31例,非重癥子癇前期(Non-SPE)29例,妊高(GH)35例和正常妊娠(NP)120例,比較疾病組和對(duì)照組的母體特征,MAP及7項(xiàng)血清學(xué)指標(biāo)。應(yīng)用Logistic和ROC曲線分析各指標(biāo)單獨(dú)或聯(lián)合時(shí)預(yù)測(cè)PE的敏感度和特異度,構(gòu)建預(yù)測(cè)PE的最優(yōu)模型。結(jié)果 (1)與NP組比較,SPE組的母齡、Non-SPE和GH組的BMI明顯增大(均P0.01);(2)PE和GH組的MAP均明顯升高,且在SPE組中升高最為顯著(均P0.01);PE組的Pl GF和PAPP-A水平較NP組均明顯降低(均P0.01),h CG水平僅在SPE組中顯著上升(P0.01);PE組中PP13、s Flt-1、s Eng和VEGF水平與NP組比較,差別均無明顯統(tǒng)計(jì)學(xué)意義。GH組的各項(xiàng)血清學(xué)指標(biāo)水平較NP組均無明顯差別;(3)Logistic回歸示SPE的最佳預(yù)測(cè)模型為:母齡聯(lián)合MAP、PAPP-A、Pl GF和HCG,AUC達(dá)0.924(95%CI:0.870~0.961;P0.01),敏感度和特異度分別為94%和78%;Non-SPE的最佳預(yù)測(cè)模型為:BMI聯(lián)合MAP、PAPP-A和Pl GF,AUC達(dá)0.877(95%CI:0.813~0.925;P0.01),敏感度和特異度分別為86%和74%。結(jié)論中孕早期聯(lián)合母體特征、MAP及母體血清學(xué)指標(biāo)PAPP-A、Pl GF、h CG的水平變化能提高PE的檢出率,且有助于評(píng)估其嚴(yán)重程度。
[Abstract]:Objective to investigate the value of combined maternal characteristics, mean arterial pressure (map) and serological markers in predicting preeclampsia (PE). Methods Blood samples were collected from pregnant women who underwent Down's screening from May 2014 to May 2015. The pregnancy outcome was followed up. 31 cases of severe preeclampsia (SPE), 29 cases of non-severe preeclampsia (Non-SPE), 35 cases of pregnancy induced hypertension (GH) and 120 cases of normal pregnancy (NP) were obtained. Map and 7 serological indexes were compared between the disease group and the control group. Logistic and ROC curves were used to analyze the sensitivity and specificity of each index in predicting PE separately or jointly, and the optimal model for PE prediction was constructed. Results (1) compared with NP group, the maternal age non-SPE and GH group were significantly increased (P0.01); (_ 2). Map of PE and GH groups were significantly higher than that of NP group. In SPE group, the levels of Pl GF and PAPP-A in PE group were significantly lower than those in NP group (P 0.01). The levels of P1GF and PAPP-A in SPE group were significantly higher than those in NP group (P0.01), and the levels of PP13s Flt-1s Eng and VEGF in PE group were significantly higher than those in NP group. There was no significant difference between GH group and NP group. (3) Logistic regression showed that the best predictive model of SPE was: maternal age combined with MAPP-AAPP-Pl GF and HCGG AUC of 0.924 (95CI 0.870 0.961P0.01), sensitivity and specificity were 94% and 78 Non-SPE, respectively. The best predictive model was: 1: BMI combined with MAPPAPP-A and Pl GFAUC 0.877 (95 CI: 0.813 0. 925 P0.01), sensitivity and specificity were 86% and 74%, respectively. Conclusion the changes of map and PAPP-A1GFhCG in early pregnancy can increase the detection rate of PE and help to evaluate the severity of PE.
【作者單位】: 北京大學(xué)深圳醫(yī)院婦產(chǎn)科北京大學(xué)深圳醫(yī)院女性重大疾病早期診斷技術(shù)重點(diǎn)實(shí)驗(yàn)室;
【基金】:深圳市知識(shí)創(chuàng)新計(jì)劃基礎(chǔ)研究項(xiàng)目(20130319184850)
【分類號(hào)】:R714.244

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 桑翠琴;張震宇;王淑珍;劉浩;郭淑麗;;重度子癇前期/子癇合并急性呼吸窘迫綜合征的診斷與處理[J];中國醫(yī)刊;2006年10期

2 趙桂花;;重度子癇前期與子癇82例臨床分析[J];臨床醫(yī)藥實(shí)踐雜志;2007年01期

3 楊小頎;嚴(yán)妮子;;子癇前期與血鈣水平相關(guān)性研究[J];實(shí)用臨床醫(yī)學(xué);2007年04期

4 楊小頎;嚴(yán)妮子;;子癇前期與血鈣水平相關(guān)性研究[J];四川生理科學(xué)雜志;2007年01期

5 陳茜;王澤華;;子癇前期的預(yù)測(cè)及預(yù)防[J];華中醫(yī)學(xué)雜志;2007年03期

6 朱倩;;對(duì)38例子癇前期(重)、子癇治愈的體會(huì)[J];實(shí)用預(yù)防醫(yī)學(xué);2007年05期

7 梁英;周麗麗;甘娟;姜碧洋;楊承東;;重度子癇前期在產(chǎn)科ICU監(jiān)護(hù)救治的臨床分析[J];中國婦幼保健;2008年19期

8 詹衛(wèi)星;鄭九生;;血管緊張素轉(zhuǎn)換酶基因多態(tài)性與重度子癇前期及腎功能損害的關(guān)系[J];江西醫(yī)藥;2008年08期

9 蔡穎;尹國武;姜鋒;李怡;閔保華;王s,

本文編號(hào):2111243


資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/fuchankeerkelunwen/2111243.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶aeddc***提供,本站僅收錄摘要或目錄,作者需要?jiǎng)h除請(qǐng)E-mail郵箱bigeng88@qq.com
久久国产亚洲精品成人| 久久精品亚洲情色欧美| 日本不卡片一区二区三区| 日本欧美一区二区三区高清| 黄色片一区二区在线观看| 色鬼综合久久鬼色88| 日韩性生活片免费观看| 欧美丰满大屁股一区二区三区| 欧美成人欧美一级乱黄| 99热在线播放免费观看| 亚洲人妻av中文字幕| 一本久道久久综合中文字幕| 国产内射一级二级三级| 国内真实露脸偷拍视频| 99视频精品免费视频播放| 在线观看视频日韩精品| 在线视频三区日本精品| 国产目拍亚洲精品区一区| 青青操视频在线播放免费| 国产成人精品国产亚洲欧洲| 久久精品久久久精品久久| 色综合久久超碰色婷婷| 国产福利一区二区三区四区| 在线观看中文字幕91| 亚洲一区二区三区日韩91| 黄色激情视频中文字幕| 日韩精品免费一区二区三区| 国产对白老熟女正在播放| 国产福利一区二区久久| 久久精品久久精品中文字幕| 亚洲国产成人精品一区刚刚| 国产亚洲欧美另类久久久| 精品一区二区三区三级视频| 欧美日韩乱码一区二区三区| 欧美一区二区三区五月婷婷| 国产精品欧美日韩中文字幕| 亚洲天堂精品在线视频| 国产精品白丝久久av| 东京热男人的天堂社区| 国产免费一区二区三区av大片| 欧美日韩精品视频在线|