本文選題：老年宮頸癌 + 腹腔鏡宮頸癌切除術(shù)��； 參考：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年19期

【摘要】：目的評(píng)價(jià)七氟烷聯(lián)合丙泊酚對(duì)老年腹腔鏡宮頸癌切除術(shù)患者術(shù)后認(rèn)知功能及血清SOD水平影響研究。方法 60例老年宮頸癌患者隨機(jī)分為對(duì)照組及試驗(yàn)組,各30例。所有患者均給予腹腔鏡下宮頸癌切除術(shù)治療,對(duì)照組給予1%~3%的七氟烷吸入進(jìn)行麻醉維持;試驗(yàn)組在對(duì)照組基礎(chǔ)上加用丙泊酚3.0 mg/(kg·h)靶控輸注。比較兩組患者手術(shù)前后血清中樞神經(jīng)特異蛋白(S100β)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平、簡(jiǎn)易智能精神狀態(tài)量表(MMSE)評(píng)分及安全性。結(jié)果治療后,與對(duì)照組比較,試驗(yàn)組患者血清SOD水平較高,MDA水平較低(P0.05)。試驗(yàn)組患者血清S100β水平較低,MMSE評(píng)分較高(P0.05)。兩組患者不良反應(yīng)發(fā)生率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論七氟烷聯(lián)合丙泊酚能夠防止血清SOD水平下降,減輕氧化應(yīng)激反應(yīng),對(duì)老年腹腔鏡宮頸癌切除術(shù)患者術(shù)后認(rèn)知功能的影響較小,且安全性較高。
[Abstract]:Objective to evaluate the effect of sevoflurane combined with propofol on cognitive function and serum SOD level in elderly patients undergoing laparoscopic cervical cancer resection. Methods 60 elderly patients with cervical cancer were randomly divided into control group and experimental group with 30 cases each. All the patients were treated with laparoscopic cervical cancer resection, the control group was treated with 1% sevoflurane inhalation for anesthesia maintenance, and the experimental group was given propofol 3.0 mg/ (kg h) target controlled infusion on the basis of the control group. The serum levels of central nervous specific protein (S100 尾), superoxide dismutase (SOD), malondialdehyde (MDA), simple mental state scale (MMSE) and safety were compared between the two groups before and after operation. Results after treatment, compared with the control group, the serum SOD level in the experimental group was higher than that in the control group (P0.05). The serum S 100 尾 level in the trial group was lower and MMSE score was higher (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion sevoflurane combined with propofol can prevent the decrease of serum SOD level and alleviate oxidative stress reaction. It has little effect on cognitive function of elderly patients undergoing laparoscopic cervical cancer resection and is more safe.
【作者單位】： 承德醫(yī)學(xué)院附屬醫(yī)院麻醉科;河北承鋼職工醫(yī)院麻醉科;河北興隆縣人民醫(yī)院麻醉科;
【分類(lèi)號(hào)】：R614;R737.33
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本文編號(hào)：2091676