本文選題：TORCH + 試管嬰兒��； 參考：《青島大學(xué)》2017年碩士論文

【摘要】：TORCH是一組能夠引起孕婦流產(chǎn)和胎兒感染,造成先天畸形或發(fā)育異常的幾種病原體的統(tǒng)稱,包括弓形體、風(fēng)疹病毒、巨細胞病毒和單純皰疹病毒為主的的四種病原體。發(fā)生TORCH感染的育齡婦女尤其是妊娠期,病原體會通過胎盤或產(chǎn)道感染胎兒,造成早產(chǎn)、流產(chǎn)、死胎、胎兒宮內(nèi)發(fā)育不良、先天畸形以及新生兒中樞神經(jīng)損害等后果。生殖醫(yī)學(xué)科的不孕患者日漸增加,由于各種原因申請試管嬰兒育齡期婦女也越來越多,TORCH感染可導(dǎo)致慣性流產(chǎn)、輸卵管堵塞以及宮頸炎癥等等,這些原因都是孕齡期婦女不孕的重要因素,也是申請試管嬰兒的適應(yīng)癥。目的:目前國內(nèi)尚無申請試管嬰兒婦女TORCH感染調(diào)查研究,本研究對來我院生殖醫(yī)學(xué)科申請試管嬰兒的不孕婦女進行常規(guī)TORCH感染篩查,以了解我院申請試管嬰兒的不孕婦女TORCH感染情況;目前國內(nèi)也尚無與產(chǎn)科或婦科篩查TORCH的病人結(jié)果對比分析的研究,通過對比分析可以了解我院申請試管嬰兒的不孕婦女和產(chǎn)科以及婦科篩查TORCH的病人感染結(jié)果的情況,從而獲得更好的提示臨床大夫關(guān)于TORCH感染情況,為優(yōu)生優(yōu)育提供更好的數(shù)據(jù)依據(jù)。方法:本文通過申請試管嬰兒婦女信息采集、血清標本采集、應(yīng)用LIAISON XL全自動化學(xué)發(fā)光免疫分析儀及其配套試劑檢測對申請試管嬰兒婦女TORCH各項Ig M和Ig G抗體檢測,利用數(shù)據(jù)統(tǒng)計分析建立數(shù)據(jù)庫;通過產(chǎn)科和婦科病人信息采集、血清標本采集、應(yīng)用LIAISON XL全自動化學(xué)發(fā)光免疫分析儀及其配套試劑檢測對申請試管嬰兒婦女TORCH各項Ig M和Ig G抗體檢測,利用數(shù)據(jù)統(tǒng)計分析建立數(shù)據(jù)庫;通過數(shù)據(jù)庫進行對比分析獲得想要的結(jié)果。結(jié)果:(1)患者年齡主要分布在25歲~30歲、30歲~35歲和35歲~40歲區(qū)段,其在申請試管嬰兒婦女所占百分比分別為32.8%、34.8%和22.8%。(2)4種病原體Ig M陽性檢出結(jié)果:TOX-Ig M陽性率為0.25%,RV-Ig M陽性率為1.47%,CMV-Ig M陽性率為1.25%和HSV(Ⅰ+Ⅱ)-Ig M為7.06%。(3)4種病原體Ig G陽性檢出結(jié)果:TOX-Ig G為0.93%、RV-Ig G為90.39%、CMV-Ig G為92.52%和HSV(Ⅰ+Ⅱ)-Ig G為97.6%。(4)三種病人RV+CMV+HSV-Ig G混合陽性所占比率最高,申請試管嬰兒病人、婦科病人和產(chǎn)科病人分別為85.69%、83.72%和80.39%。三種病人各種病原體均陰性所占比率產(chǎn)科最高為2.34%,其次為申請試管嬰兒患者為0.97%,婦科患者最低為0.47%。(5)三種病人均以TORCH-Ig M陰性為主,產(chǎn)科最高為95.3%,其次為婦科患者91.35%,最低為申請試管嬰兒的患者90.32%;三種病人均以HSV(Ⅰ+Ⅱ)-Ig M陽性為最高,產(chǎn)科病人為3.16%,申請試管嬰兒患者為6.81%,婦科病人為4.20%。結(jié)論:(1)我院申請試管嬰兒育齡期婦女年齡以25-40歲之間為主。(2)4種病原體Ig G陽性率以弓形蟲最低,其它3種均較高,單純皰疹病毒為最高。(3)4種病原體以Ig G陽性作為分類表明以RV+CMV+HSV病原體混合感染為最高,單純感染所占比率及陰性患者均較低。(4)Ig M陽性作為分類表明,以Ig M陰性為主,混合感染所占比率較低。(5)三種患者TORCH-Ig G篩查結(jié)果中RV+CMV+HSV混合感染以申請試管嬰兒為最高,感染情況比婦科和產(chǎn)科患者要嚴重。(6)三種患者TORCH-Ig M篩查結(jié)果中申請試管嬰兒的患者HSV(Ⅰ+Ⅱ)-Ig M比率最高,其它三種病原體均介于產(chǎn)科與婦科患者之間。
[Abstract]:TORCH is a group of pathogens that can cause abortion and fetal infection, cause congenital malformation or abnormal development of several pathogens, including Toxoplasma, rubella virus, cytomegalovirus and herpes simplex virus four pathogens. TORCH infected women of childbearing age, especially pregnancy, are infected by placenta or birth canal infection. Fetus, resulting in premature birth, abortion, stillbirth, fetal intrauterine dysplasia, congenital malformation, and neonatal central nerve damage. Infertility patients in the reproductive medical department are increasing. For various reasons, more and more women of childbearing age are applied for test tube infants, TORCH infection can lead to inertial abortion, tubal blockage and cervicitis and so on. These reasons are important factors for infertility in pregnant women and are also suitable for the application of test tube infants. Objective: at present, there is no investigation and Study on TORCH infection in test tube baby women. This study is a routine screening of TORCH infection for infertile women in the Department of reproductive medicine of our hospital to understand our application for test tube infants. At present, there is no comparative analysis of the results of the patients with obstetric or gynecologic screening of TORCH in China. Through comparative analysis, we can get a better understanding of the infection results of the patients who have applied for the infertility women and obstetrics and the gynecologic screening of TORCH in TORCH, so as to get a better indication of the clinical doctor about the TO. RCH infection conditions provide a better data basis for eugenics. Methods: by applying the information collection of the test tube baby women, the collection of serum specimens, the application of the LIAISON XL full automatic chemiluminescence immunoassay analyzer and its matching reagents to test the Ig M and Ig G antibodies of the application test tube baby women's Ig M and Ig G. The data collection of the obstetric and gynecologic patients, the collection of serum samples, the application of LIAISON XL full automatic chemiluminescence immunoassay analyzer and its matching reagents to test the TORCH Ig M and Ig G antibody of the application test tube baby women, and establish the data base by the statistical analysis of the data, and obtain the desired results through the comparative analysis of the database. Results: (1) the age of the patients was mainly distributed at the age of 25 years old ~30, 30 year old ~35 and 35 year old ~40, and the percentage of women in the application for test tube infants was 32.8%, 34.8% and 22.8%. (2) of Ig M positive results: the positive rate of TOX-Ig M was 0.25%, the positive rate of RV-Ig M was 1.47%, CMV-Ig M positive rate was 1.25% and CMV-Ig M (I + II). The positive results of 7.06%. (3) 4 pathogens were positive: TOX-Ig G was 0.93%, RV-Ig G was 90.39%, CMV-Ig G was 92.52% and HSV (I + II), -Ig G was the highest proportion of three patients (4). The application for test tube infants, gynecologic and family patients were 85.69%, 83.72% and three of the patients. The highest rate of all negative obstetrical obstetrics was 2.34%, followed by 0.97% for test tube infants, 0.97% for gynaecologic patients and 0.47%. (5) in gynecologic patients (5), with TORCH-Ig M negative, 95.3% in obstetrics, 91.35% in gynecologic patients and 90.32% for patients who applied for test tube infants; and three patients with HSV (I + II) -Ig M positive as the most High, obstetric patients 3.16%, 6.81% for test tube infants and 4.20%. for gynecologic patients: (1) the age of women of childbearing age in our hospital was 25-40 years old. (2) the Ig G positive rate of 4 pathogens was the lowest, the other 3 were higher, and the Dan Chunpao rash virus was the highest. (3) 4 pathogens were classified as Ig G positive as the classification table. RV+CMV+HSV pathogen mixed infection was the highest, the ratio of simple infection and negative patients were low. (4) Ig M positive as the classification showed that Ig M negative mainly, the ratio of mixed infection was lower. (5) the three cases of TORCH-Ig G screening results of RV+CMV+HSV mixed infection to apply for test tube infants is the highest, infection than gynecology and production. The patients were serious. (6) the rate of HSV (I + II) -Ig M was the highest in the results of TORCH-Ig M screening, and the other three pathogens were between obstetric and gynecologic patients.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R714.8

【參考文獻】

相關(guān)期刊論文 前10條

1 章錦曼;阮強;張寧;李利;葉漢風(fēng);馬艷萍;董旭東;孟昱時;朱寶生;李金明;;TORCH感染篩查、診斷與干預(yù)原則和工作流程專家共識[J];中國實用婦科與產(chǎn)科雜志;2016年06期

2 王甲甲;王智斌;黃文芳;;TORCH病原體感染與自然流產(chǎn)的關(guān)系及影響因素[J];中國計劃生育和婦產(chǎn)科;2015年07期

3 唐慧靜;張彬;;2900例孕前及孕早期婦女TORCH篩查結(jié)果分析[J];中國優(yōu)生與遺傳雜志;2015年03期

4 ;妊娠期ToRCH篩查指南[J];解放軍醫(yī)藥雜志;2014年01期

5 丁舫;王榴紅;;孕婦血清TORCH四種病原體感染血清學(xué)篩選的臨床分析[J];放射免疫學(xué)雜志;2013年06期

6 賀娜珍;劉麗萍;胡碧燕;;普陀區(qū)圍孕期婦女TORCH感染篩查結(jié)果分析[J];中華醫(yī)院感染學(xué)雜志;2013年21期

7 周愛華;管愛軍;崔劍;惠娟;;14862例婚檢和孕檢女性血液傳染病及TORCH感染指標檢測結(jié)果分析[J];檢驗醫(yī)學(xué)與臨床;2013年11期

8 張欠欠;成俊珍;王逢會;;TORCH感染與不良妊娠結(jié)局的相關(guān)性分析[J];中國血吸蟲病防治雜志;2013年02期

9 高章圈;張亦心;李國正;田慧艷;陳拽生;趙惠芬;劉效群;馬靜;韓瑞鈺;宗文平;姚冠峰;;河北省80699例已婚女性孕前TORCH檢測結(jié)果分析[J];中國婦幼保健;2012年20期

10 李珉珉;曾正坤;朱勤愛;朱穗蘭;;3640例育齡產(chǎn)婦TORCH篩查回顧性分析[J];熱帶醫(yī)學(xué)雜志;2012年02期

，

本文編號：2087155