本文選題：中西醫(yī)結(jié)合治療 + 臨床研究�。� 參考：《揚(yáng)州大學(xué)》2016年碩士論文

【摘要】：目的：通過(guò)臨床研究,探討中藥聯(lián)合來(lái)曲唑與單純應(yīng)用中藥補(bǔ)腎調(diào)周療法和單純應(yīng)用來(lái)曲唑?qū)β雅莅l(fā)育不良的治療效果。通過(guò)比較臨床癥狀、卵泡發(fā)育狀況、內(nèi)膜厚度、妊娠率等各方面的差異,獲得針對(duì)不同卵泡發(fā)育不良患者的最佳療法。方法：選自2013年09月至2015年08月,在揚(yáng)州市第一人民醫(yī)院(西區(qū)),按照臨床診斷標(biāo)準(zhǔn)選取90例卵泡發(fā)育不良的患者。隨機(jī)分組,每組各30例,分別為中藥組、西藥組以及中藥聯(lián)合西藥組(以下稱(chēng)聯(lián)合組)。西藥組口服來(lái)曲唑,于月經(jīng)來(lái)潮第五天開(kāi)始口服。中藥組按月經(jīng)周期口服補(bǔ)腎調(diào)周方治療,聯(lián)合組按月經(jīng)周期口服補(bǔ)腎調(diào)周方同時(shí)并用來(lái)曲唑治療,三組均治療三個(gè)月。按照病例排除標(biāo)準(zhǔn),剔除不符合病例后,總結(jié)得：西藥組29例；中藥組29例；聯(lián)合用藥組30例。記錄患者治療前后的卵泡大小、內(nèi)膜厚度、E2、臨床積分、妊娠率等情況；所得數(shù)據(jù)采用SPSS16.0統(tǒng)計(jì)分析軟件處理,計(jì)量數(shù)據(jù)用均數(shù)士標(biāo)準(zhǔn)差(x±s)表達(dá)；采取單因素方差分析統(tǒng)計(jì)樣本治療前有無(wú)差異性,治療前后資料進(jìn)行配對(duì)樣本的t檢驗(yàn)；組間比較用獨(dú)立樣本的t檢驗(yàn)；計(jì)數(shù)資料用卡方檢驗(yàn)。結(jié)果：治療前后相比,三組患者在臨床癥狀、卵泡發(fā)育狀況、排卵率、子宮內(nèi)膜厚度均有改善(P0.05)；治療后組間比較,在卵泡發(fā)育上中藥組與聯(lián)合組之間P0.05,聯(lián)合組優(yōu)于中藥組；內(nèi)膜厚度上西藥組與聯(lián)合組在內(nèi)膜厚度上存在差異P0.05,聯(lián)合組優(yōu)于西藥組；在臨床癥狀的治療上,中藥組與聯(lián)合組要優(yōu)于西藥組P0.05；聯(lián)合組的妊娠率要高于西藥組P0.05；聯(lián)合組的卵泡成熟率高于中藥組P0.05；聯(lián)合組在排卵后的黃體功能優(yōu)于西藥組P0.05；中藥組、西藥組的E2水平、LUFS的發(fā)生率均與聯(lián)合組無(wú)明顯差別P0.05。結(jié)論：中藥聯(lián)合來(lái)曲唑應(yīng)用在縮短治療周期,改善患者臨床癥狀、提高排卵率、妊娠率增加子宮內(nèi)膜厚度,提高黃體功能等方面明顯優(yōu)于單純應(yīng)用中藥或單純應(yīng)用西藥。
[Abstract]:Objective: to investigate the therapeutic effect of traditional Chinese medicine combined with letrozole on follicular dysplasia with traditional Chinese medicine (TCM) combined with traditional Chinese medicine (TCM) for tonifying the kidney and regulating the week. By comparing the clinical symptoms, follicular development, intimal thickness and pregnancy rate, the best treatment for patients with different follicular dysplasia was obtained. Methods: from September 2013 to August 2015, 90 patients with follicular dysplasia were selected in Yangzhou first people's Hospital (Western region) according to clinical diagnostic criteria. They were randomly divided into three groups: the traditional Chinese medicine group, the western medicine group and the combined Chinese medicine group (hereinafter referred to as the combined group). The western medicine group took letrozole orally and began on the fifth day of menstruation. The traditional Chinese medicine group was treated by oral tonifying kidney and weekly prescription according to menstrual cycle, and the combined group was treated with triazole simultaneously according to menstrual cycle. All the three groups were treated for three months. According to the criteria of exclusion of cases, the results were summarized as follows: 29 cases in western medicine group, 29 cases in traditional Chinese medicine group and 30 cases in combination group. The follicle size, intimal thickness, clinical score, pregnancy rate and so on were recorded before and after treatment, the data were processed by SPSS 16.0 statistical analysis software, and the measured data were expressed by the mean standard deviation (x 鹵s). Single factor analysis of variance (ANOVA) was used to analyze whether there was any difference before and after treatment. Before and after treatment, the matched samples were tested by t test; the independent samples were used by t test for the comparison between groups; and the counting data were tested by chi-square test. Results: compared with before and after treatment, the clinical symptoms, follicle development, ovulation rate and endometrial thickness of the three groups were improved (P0.05), and after treatment, the Chinese medicine group and the combined group were better than the traditional Chinese medicine group in follicular development (P 0.05). There was a difference in intimal thickness between the western medicine group and the combined group (P 0.05), the combination group was superior to the western medicine group, the traditional Chinese medicine group and the combined group were better than the western medicine group (P 0.05) in the treatment of clinical symptoms, the pregnancy rate of the combined group was higher than that of the western medicine group (P 0.05). The follicular maturation rate in the combined group was higher than that in the traditional Chinese medicine group, the luteal function after ovulation in the combined group was better than that in the western medicine group (P0.05), and the incidence of E2 level and LUFS in the traditional Chinese medicine group and western medicine group were not significantly different from those in the combined group (P 0.05). Conclusion: traditional Chinese medicine combined with letrozole is superior to traditional Chinese medicine or western medicine in shortening treatment cycle, improving clinical symptoms, increasing ovulation rate, increasing endometrial thickness and improving luteal function.
【學(xué)位授予單位】：揚(yáng)州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R711.6

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