本文選題：人絨毛膜促性腺激素 + 孕酮��； 參考：《河北聯(lián)合大學(xué)》2014年碩士論文

【摘要】：目的探討妊娠4～9周婦女血清人絨毛膜促性腺激素（human chorionicgonadotropin，hCG）、孕酮（progesterone，P）、雌二醇（estrone，E2）及睪酮（testosterone，T）等4種激素水平在不同妊娠結(jié)局組的差異，并分析該4種激素隨孕周增長的變化。 方法選擇早期宮內(nèi)單胎妊娠婦女314例進行問卷調(diào)查，無內(nèi)外科合并癥，隨訪至孕3月末，采用化學(xué)發(fā)光分析法檢測所有孕婦空腹血清hCG、P、E2及T水平，根據(jù)妊娠結(jié)局、孕周及臨床癥狀進行分組，用SPSS16.0軟件對結(jié)果進行統(tǒng)計分析。 結(jié)果1314例早期宮內(nèi)單胎妊娠婦女，正常妊娠者167例（正常妊娠組，53.18%），異常妊娠者147例（異常妊娠組，46.82%）。異常妊娠組中先兆流產(chǎn)者102例（先兆流產(chǎn)組，69.39%），難免流產(chǎn)者29例（難免流產(chǎn)組，19.73%），稽留流產(chǎn)者16例（稽留流產(chǎn)組，10.88%）。早孕期妊娠丟失者占妊娠總數(shù)的14.33%（45/314）。2正常妊娠組的血清HCG、E2及T水平與孕周均呈正相關(guān)（血清HCG：r=0.57，P=0.00；血清E2：r=0.62，P=0.00；血清T：r=0.24，P=0.00），血清P水平與孕周無相關(guān)性（r=0.15，P=0.06）。3正常妊娠組的血清P水平95%參考值范圍為（81.98～90.50）nmol/L，血清E2水平95%參考值范圍為（2826.2～3383.0）pmol/L。4相同孕周，，正常妊娠組的血清E2水平均高于異常妊娠組（P均0.05）。5并聯(lián)法指標聯(lián)合檢測4種激素水平對診斷異常妊娠的靈敏度可高達94.83%。 結(jié)論1正常妊娠組的血清HCG、E2及T水平與孕周呈正相關(guān)，但血清P水平處于相對恒定水平，不隨孕周發(fā)生變化。2妊娠4～9周，正常妊娠組的血清E2水平均高于異常妊娠組。3聯(lián)合檢測血清hCG、E2、P及T水平更有利于預(yù)測早孕期的妊娠結(jié)局。
[Abstract]:Objective to investigate the differences of serum levels of human chorionic gonadotropin (hCG), progesterone (P), estradiol (E 2) and testosterone (T) in women with 4 weeks of gestation in different pregnancy outcome groups, and to analyze the changes of these four hormones with gestational weeks. Methods A questionnaire survey was conducted in 314 women with early intrauterine single pregnancy. All pregnant women were followed up until the third trimester of pregnancy. The fasting serum levels of hCGG PnP E 2 and T were measured by chemiluminescence assay, according to the outcome of pregnancy. Gestational age and clinical symptoms were divided into groups and the results were statistically analyzed by SPSS 16.0 software. Results among 1314 cases of early intrauterine single pregnancy, 167 cases were normal pregnancy (53.18% of normal pregnancy group) and 147 cases of abnormal pregnancy group (46.82% of abnormal pregnancy group). There were 102 cases of threatened abortion (69.39%), 29 cases of inevitable abortion (19.73%) and 16 cases of missed abortion (10.88%) in abnormal pregnancy group. (2) the serum levels of HCG E 2 and T in normal pregnancy group were positively correlated with gestational weeks (HCG: r 0.57 P 0.00; E 2: r 0.62 P 0.00; E 2: r 0.62 P 0.00). There was no correlation between serum P level and gestational week (r = 0.15). 3 the reference range of serum P level in normal pregnancy group was (81.98 / 90.50) nmol / L, and the reference range of serum E _ 2 level 95% was (2826.2383.0) pmol / L.4 for the same gestational week. The serum E2 level in normal pregnancy group was significantly higher than that in abnormal pregnancy group (P 0.05). The sensitivity of combined detection of four hormones in abnormal pregnancy was 94.83%. Conclusion (1) the levels of serum HCG E 2 and T in normal pregnancy group were positively correlated with gestational week, but the serum P level was relatively constant and did not change with gestational week .2 at 4 weeks of gestation. The level of serum E2 in normal pregnancy group was higher than that in abnormal pregnancy group. Combined determination of serum hCGE2P and T levels was helpful to predict pregnancy outcome in early pregnancy.
【學(xué)位授予單位】：河北聯(lián)合大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R714.1

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