本文選題：絲切蛋白 + 前纖維蛋白　； 參考：《中國醫(yī)科大學學報》2015年01期

【摘要】：目的探究絲切蛋白1(CFL1)及前纖維蛋白1(PFN1)在外陰鱗狀細胞癌(VSCC)中的表達與意義。方法采用免疫組化和免疫印跡方法檢測CFL1及PFN1在VSCC中的表達及其與臨床病理資料相關(guān)性。結(jié)果 CFL1在VSCC中的表達顯著高于外陰的正常皮膚(P0.05);臨床Ⅲ期的表達明顯高于Ⅰ、Ⅱ期(P0.05);在低分化、中分化的VSCC中的表達明顯高于高分化VSCC(P0.05);伴淋巴結(jié)轉(zhuǎn)移的表達明顯高于無淋巴結(jié)轉(zhuǎn)移(P0.05)。PFN1在VSCC中的表達顯著高于外陰的正常皮膚(P0.05);臨床Ⅲ期的表達明顯高于Ⅰ、Ⅱ期(P0.05);伴淋巴結(jié)轉(zhuǎn)移的表達明顯高于無淋巴結(jié)轉(zhuǎn)移(P0.05);VSCC低、中分化和高分化之間沒有統(tǒng)計學差異(P0.05)。Pearson相關(guān)性分析結(jié)果表明:CFL1及PFN1在VSCC中的表達呈正相關(guān)(r2=0.753,P0.001)。結(jié)論 CFL1及PFN1的表達與VSCC的發(fā)生和發(fā)展有關(guān)。
[Abstract]:Objective to investigate the expression and significance of CFL1 and PFN1 in vulvar squamous cell carcinoma (VSCC). Methods the expression of CFL1 and PFN1 in VSCC was detected by immunohistochemistry and Western blot. Results the expression of CFL1 in VSCC was significantly higher than that in vulvar normal skin (P0.05), the expression of CFL1 in clinical stage 鈪，

本文編號：2075162