本文選題：子宮內(nèi)膜癌 + 炎癥　； 參考：《廣西醫(yī)科大學》2014年碩士論文

【摘要】：目的：檢測正常子宮內(nèi)膜、不典型增生子宮內(nèi)膜及子宮內(nèi)膜癌中炎癥因子NF-κB及COX-2的表達情況,分析其與子宮內(nèi)膜癌臨床病理特征之間的關系,以探討它們在子宮內(nèi)膜癌發(fā)生、發(fā)展及預后評估中的作用。 方法：采用免疫組化SP法,檢測正常子宮內(nèi)膜、不典型增生子宮內(nèi)膜和子宮內(nèi)膜癌中NF-KB/p65和COX-2的表達水平,比較它們在不同子宮內(nèi)膜組織中表達的差異,分析其表達與子宮內(nèi)膜癌FIGO分期、組織學分級、肌層浸潤深度、淋巴結(jié)有無轉(zhuǎn)移及病理類型的關系。 結(jié)果：從正常子宮內(nèi)膜、不典型增生子宮內(nèi)膜到子宮內(nèi)膜癌,NF-κB/p65和COX-2的陽性表達率逐漸增高,p65在三組間表達差異有統(tǒng)計學意義(P0.05),而COX-2的表達差異無統(tǒng)計學意義(P0.05)。在子宮內(nèi)膜癌中,p65表達與組織學分級有關,與FIGO分期、肌層浸潤深度、淋巴轉(zhuǎn)移和病理類型無相關；COX-2與FIGO分期、組織學分級、肌層浸潤深度、淋巴轉(zhuǎn)移和病理類型均無相關。 結(jié)論：NF-κB/p65的活化可能是子宮內(nèi)膜癌的早期事件,與子宮內(nèi)膜癌的發(fā)生有關。在子宮內(nèi)膜癌中,NF-κB/p65的表達與組織分化程度有關,提示NF-κB/p65可能與子宮內(nèi)膜癌的惡性程度相關,可能成為判斷預后的指標之一。COX-2在正常子宮內(nèi)膜、不典型增生子宮內(nèi)膜和子宮內(nèi)膜癌中的表達率差別無統(tǒng)計學意義。在子宮內(nèi)膜癌中,COX-2的表達與FIGO分期、組織學分級、肌層浸潤深度、淋巴結(jié)轉(zhuǎn)移及組織病理類型等無明顯關系。
[Abstract]:Objective: to detect the expression of inflammatory factors NF- 魏 B and COX-2 in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma, and analyze the relationship between them and clinicopathological features of endometrial carcinoma. The role of development and prognostic evaluation. Methods: immunohistochemical SP method was used to detect the expression of NF-KB / p65 and COX-2 in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma. The relationship between expression and Figo stage, histological grade, depth of myometrium invasion, lymph node metastasis and pathological type of endometrial carcinoma were analyzed. Results: from normal endometrium, atypical hyperplasia endometrium to endometrial carcinoma, the positive rate of NF- 魏 B / p65 and COX-2 increased gradually (P0.05), but the difference of COX-2 expression was not significant (P0.05). The expression of p65 in endometrial carcinoma was related to histological grade, but not to Figo stage, depth of myometrial invasion, lymphatic metastasis and pathological type. There was no correlation between COX-2 and Figo stage, histological grade, depth of myometrial invasion, lymphatic metastasis and pathological type. Conclusion the activation of 10% NF- 魏 B / p65 may be an early event in endometrial carcinoma and may be related to the occurrence of endometrial carcinoma. The expression of NF- 魏 B / p65 in endometrial carcinoma is related to the degree of tissue differentiation, suggesting that NF- 魏 B / p65 may be associated with the malignancy of endometrial carcinoma, and may be one of the prognostic markers of COX-2 in normal endometrium. There was no significant difference in the expression rate between atypical hyperplasia endometrium and endometrial carcinoma. The expression of COX-2 in endometrial carcinoma was not correlated with Figo stage, histological grade, depth of myometrial invasion, lymph node metastasis and histopathological type.
【學位授予單位】：廣西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R737.33

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