本文選題：保婦康栓 + 混合性陰道感染�。� 參考：《實(shí)用婦產(chǎn)科雜志》2015年06期

【摘要】：目的:研究中成藥保婦康栓調(diào)節(jié)陰道微生態(tài)平衡對治療外陰陰道假絲酵母菌病(VVC)合并細(xì)菌性陰道病(BV)的臨床意義。方法:采用前瞻性、隨機(jī)、劑量組平行對照臨床實(shí)驗(yàn),將51例VVC合并BV的患者,分為保婦康栓組26例,甲硝唑聯(lián)合硝酸咪康唑栓組(聯(lián)合組)25例,分析兩組患者在停藥第7±3天和第28±5天的癥狀改善及實(shí)驗(yàn)室檢查方面的變化,采用Nugent評分進(jìn)行BV診斷及療效評價(jià)。結(jié)果:第1次隨訪:保婦康栓組與聯(lián)合組Nugent評分、減分率比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),兩組p H值、乳桿菌分級差異無統(tǒng)計(jì)學(xué)意義(P0.05);保婦康栓組與聯(lián)合組患者外陰瘙癢、白帶異味、白帶增多不適癥狀比率較入組時(shí)均下降,但兩組比較差異無統(tǒng)計(jì)學(xué)意義(P0.05);此外,兩組患者VVC痊愈率(76.92%vs 88.00%)比較差異無統(tǒng)計(jì)學(xué)意義(P0.05),而BV痊愈率(38.46%vs 76.00%)差異有統(tǒng)計(jì)學(xué)意義(P0.05)。第2次隨訪:保婦康栓組較聯(lián)合組p H值、Nugent評分及減分率差異均無統(tǒng)計(jì)學(xué)意義(P0.05);保婦康栓組15例患者的乳桿菌分級均達(dá)到Ⅰ級或Ⅱ級,恢復(fù)到正常水平,而聯(lián)合組仍有2例未達(dá)到正常水平,但兩組比較差異無統(tǒng)計(jì)學(xué)意義(P0.05);保婦康栓組患者外陰瘙癢、白帶異味、白帶增多不適癥狀比率較第1次隨訪時(shí)進(jìn)一步下降,而聯(lián)合組外陰瘙癢、白帶異味、白帶增多癥狀比例上升,其中聯(lián)合組有2例外陰瘙癢、1例白帶異味可能有復(fù)發(fā)情況發(fā)生,但兩組比較差異不顯著(P0.05);保婦康栓組與聯(lián)合組患者BV均100%痊愈,保婦康栓組VVC復(fù)發(fā)率(6.67%)低于聯(lián)合組(11.76%),兩組比較差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:保婦康栓能有效治療VVC合并BV,能恢復(fù)陰道微生態(tài)平衡,作用較抗生素和緩、復(fù)發(fā)率低,值得在臨床全面推廣應(yīng)用。
[Abstract]:Objective: to study the clinical significance of traditional Chinese patent medicine Baofukang suppository in regulating the balance of vaginal microecology in the treatment of vulvovaginal candidiasis with bacterial vaginosis (BV). Methods: Fifty-one patients with VVC combined with BV were divided into two groups: 26 cases in Baofukang suppository group and 25 cases in metronidazole combined with miconazole nitrate suppository group. The changes of symptoms and laboratory examination on the 7th 鹵3rd and 28th 鹵5 days after withdrawal were analyzed in the two groups. The BV diagnosis and curative effect were evaluated by Nugent score. Results: during the first follow-up, the Nugent score of Baofukang suppository group and the combined group were significantly lower than that of the control group (P 0.05). There was no significant difference in pH value and Lactobacillus grade between the two groups, and there was no significant difference between the two groups in the treatment of vulvar pruritus, leukorrhea, and abnormal smell of leucorrhea. In addition, there was no significant difference in the recovery rate of VVC between the two groups (76.92 vs 88.00), but there was no significant difference in the recovery rate of BV (38.46 vs 76.00). The second follow-up showed that there was no significant difference in pH value, Nugent score and score reduction rate between Baofukang suppository group and combined group, and 15 patients in Baofukang suppository group had Lactobacillus grade 鈪，

本文編號：2036864