本文選題：體外受精 + 精漿彈性硬蛋白酶　； 參考：《山東醫(yī)藥》2017年05期

【摘要】：目的探討精漿彈性硬蛋白酶對(duì)體外受精-胚胎移植(IVF-ET)正常受精、優(yōu)質(zhì)胚胎的影響。方法選擇因女方輸卵管因素行促性腺激素釋放激素激動(dòng)劑長(zhǎng)方案卵巢控制性刺激的1 183對(duì)周期不孕夫婦。按照男性生殖系統(tǒng)感染情況將女性分為三組:未感染(精漿彈性硬蛋白酶水平290 ng/m L)組703例、隱性感染(精漿彈性硬蛋白酶水平290~1 000 ng/m L)組385例、確證感染(精漿彈性硬蛋白酶水平1 000 ng/m L)組95例。排除獲卵數(shù)≤5個(gè)或≥20個(gè)、女方年齡≥35歲,三組經(jīng)校正后未感染組159例、隱性感染組137例、感染組41例。均行IVFET,對(duì)比各組校正前后正常受精率、優(yōu)質(zhì)胚胎率。結(jié)果校正前三組正常受精率、優(yōu)質(zhì)胚胎率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P均0.05)。校正后三組正常受精率比較差異有統(tǒng)計(jì)學(xué)意義(P0.05),優(yōu)質(zhì)胚胎率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);與隱性感染組、未感染組比較,感染組正常受精率降低(P0.017)。結(jié)論排除女方高齡、卵巢低反應(yīng)及卵巢高反應(yīng)人群,卵巢正常儲(chǔ)備女性其丈夫精漿彈性硬蛋白酶水平對(duì)IVF-ET正常受精率有影響,對(duì)優(yōu)質(zhì)胚胎率影響不大。
[Abstract]:Objective to investigate the effect of seminal plasma elastic hard proteinase on normal fertilization and high quality embryos in vitro fertilization and embryo transfer (IVF-ET). Methods 1183 couples with cyclical infertility due to the long scheme of gonadotropin releasing hormone agonists were selected because of female fallopian tube factors. Women were divided into three groups according to the male reproductive system infection. No infection (seminal plasma elastic hard proteinase level 290 ng/m L) group 703 cases, recessive infection (seminal elastic hard proteinase level 290~1 000 ng/m L) group 385 cases, confirmed infection (seminal plasma elastic hard proteinase level 1000 ng/m L) group 95 cases. Exclude the number of eggs less than 5 or more than 20, the female age is more than 35 years old, three groups after correction of the group 159 cases, hidden sexy group, implicit sex 137 cases and 41 cases of infection group were treated with IVFET. The normal fertilization rate and high quality embryo rate were compared before and after correction. The results of normal fertilization rate in the first three groups were corrected. The difference of high quality embryo rate was not statistically significant (P 0.05). The difference of normal fertilization rate in the three groups was statistically significant (P0.05), and there was no statistical difference between the high quality embryo rate and the rate of high quality embryos. P0.05; compared with the recessive infection group, the normal fertilization rate in the infected group was lower than that in the uninfected group (P0.017). Conclusion excluding the female age, the ovarian hyper reaction and the ovarian hyper response population, the normal ovarian reserve of the women whose husbands' seminal elastic hard protease levels have an influence on the normal fertilization rate of IVF-ET, and have little effect on the high quality embryo rate.
【作者單位】： 山東中醫(yī)藥大學(xué);山東中醫(yī)藥大學(xué)附屬醫(yī)院;山東省婦幼保健院;
【基金】：山東省重點(diǎn)研發(fā)計(jì)劃項(xiàng)目(2015GSF119018)
【分類(lèi)號(hào)】：R714.8

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