發(fā)布時間：2018-06-16 12:17

  本文選題：宮頸癌 + 局部感染��； 參考：《中華醫(yī)院感染學(xué)雜志》2015年10期

【摘要】：目的探討宮頸癌患者近距離放療后局部感染情況,分析陰道分泌物的病原菌分布及耐藥性,為臨床防治局部感染提供依據(jù)。方法選取2013年1月-2014年12月醫(yī)院就診并實施近距離放療的356例宮頸癌患者為研究對象,調(diào)查分析患者放療后局部感染情況、陰道分泌物病原菌分布及其耐藥性。結(jié)果 356例患者中68例發(fā)生局部感染,感染率為19.1%;共分離病原菌75株,其中革蘭陰性菌50株占66.7%,以大腸埃希菌和奇異變形菌為主,革蘭陽性菌22株占29.3%,以葡萄球菌屬和腸球菌屬為主,真菌3株占4.0%,以白色假絲酵母菌為主,大腸埃希菌對頭孢噻肟、頭孢吡肟、頭孢他啶、阿莫西林、哌拉西林、環(huán)丙沙星和慶大霉素耐藥率較高,耐藥率為62.5%~93.8%;奇異變形菌對阿莫西林和慶大霉素耐藥率較高,耐藥率為66.7%和55.6%;葡萄球菌屬對青霉素G、紅霉素、環(huán)丙沙星、左氧氟沙星和氨芐西林高度耐藥,耐藥率為53.8%~92.3%;腸球菌屬對慶大霉素、紅霉素和左氧氟沙星高度耐藥,耐藥率為66.7%~100.0%。結(jié)論宮頸癌近距離放療合并局部感染率較高,臨床應(yīng)加強感染病原菌檢測,掌握病原菌種類及其耐藥性,指導(dǎo)臨床合理使用抗菌藥物,提高患者臨床治療效果。
[Abstract]:Objective to investigate the local infection in patients with cervical cancer after brachytherapy, and to analyze the distribution and drug resistance of vaginal secretions in order to provide evidence for clinical prevention and treatment of local infections. Methods 356 patients with cervical cancer were selected from January 2013 to December 2014 and received brachytherapy. The local infection, the distribution of pathogenic bacteria in vaginal secretions and their drug resistance were investigated and analyzed. Results Local infection occurred in 68 of 356 patients, and the infection rate was 19.1.A total of 75 strains of pathogenic bacteria were isolated, of which 50 strains were Gram-negative bacteria (66.7%), mainly Escherichia coli and Proteus mirabilis. 22 strains of Gram-positive bacteria accounted for 29.3%, mainly Staphylococcus and Enterococcus, fungi 3 strains were 4.0, mainly Candida albicans, Escherichia coli to cefotaxime, cefepime, ceftazidime, amoxicillin, piperacillin, The resistant rates of ciprofloxacin and gentamycin were higher (62.5%, 93.8%), amoxicillin and gentamicin resistance rates were higher (66.7% and 55.6%), Staphylococcus belonged to penicillin G, erythromycin, ciprofloxacin, staphylococci were resistant to penicillin G, erythromycin and ciprofloxacin, the resistance rates of Proteus mirabilis to amoxicillin and gentamycin were 66.7% and 55.6%, respectively. Levofloxacin and ampicillin were highly resistant, the resistance rate was 53.8% and 92.3%, and Enterococcus was highly resistant to gentamicin, erythromycin and levofloxacin, and the resistance rate was 66.7%. Conclusion the local infection rate of cervical cancer combined with brachytherapy is high. It is necessary to strengthen the detection of pathogenic bacteria, master the types of pathogens and their drug resistance, guide the rational use of antimicrobial agents in clinic and improve the clinical therapeutic effect.
【作者單位】： 浙江省腫瘤醫(yī)院婦瘤放療科;
【基金】：浙江省醫(yī)學(xué)高等�？茖W(xué)�？蒲谢鹳Y助項目(2009XZB04)
【分類號】：R737.33

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相關(guān)期刊論文 前3條

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本文編號：2026626