本文選題：青春期 + 多囊卵巢綜合征�。� 參考：《湖南中醫(yī)藥大學》2014年碩士論文

【摘要】：目的 觀察針刺聯合二甲雙胍治療肝經郁熱型青春期多囊卵巢綜合征在中醫(yī)癥狀、高雄激素體征及性激素等方面的影響,評價該療法的臨床有效性及安全性,探討其作用機理。 方法 收集60例肝經郁熱型青春期多囊卵巢綜合征患者,隨機分為治療組、對照組各30例。治療組予針刺聯合口服二甲雙胍,對照組予口服二甲雙胍,均治療三個月。在治療前及治療3個月后,于月經第3天采集空腹靜脈血,測定血清睪酮(T)、黃體生成素(LH)、卵泡刺激素(FSH)、空腹胰島素(FINS)、空腹血糖(FPG),并觀察中醫(yī)證候、高雄激素體征、B超等變化。 結果 兩組月經異常、痤瘡、中醫(yī)證候總積分、卵巢體積、卵泡數目前后比較均有顯著統計學差異(P0.01),多毛無統計學差異(P0.05)。治療后比較,痤瘡、中醫(yī)證候總積分有統計學差異(P0.05),月經異常積分、卵巢體積、卵泡數目無統計學差異(P0.05)。中醫(yī)證候療效比較,針藥組總有效率為83.33%,西藥組總有效率為63.33%,差異具有統計學意義(P0.05)。兩組T值治療前后比較,有顯著統計學差異(P0.01),兩組治療后比較,有統計學差異(P0.05)。兩組治療后LH、LH/FSH值比治療前均明顯降低,有顯著統計學差異(P0.01),兩組治療后比較,有顯著統計學差異(P0.01)；血清FSH、FPG值兩組治療前后均無統計學差異(P0.05)。針藥組FINS治療前后比較有統計學差異(P0.05),西藥組FINS、兩組HOMA-IR直治療前后有顯著統計學差異(P0.01)；兩組FINS、HOMA-IR治療后比較差異無統計學意義(P0.05)。 結論 針刺聯合二甲雙胍對肝經郁熱型青春期PCOS是安全、有效的治療方法,可降低患者血清T、LH、LH/FSH、FINS、HOMA-IR,使患者月經規(guī)則、高雄激素癥狀減輕,卵巢體積、卵泡數減小,總體療效優(yōu)于單純口服二甲雙胍。
[Abstract]:Objective to observe the effects of acupuncture combined with metformin on the symptoms, signs of hyperandrogen and sex hormones in the treatment of liver meridian and heat type puberty polycystic ovary syndrome (PCOS), and to evaluate the clinical efficacy and safety of the therapy. Methods 60 patients with PCOS were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with acupuncture combined with metformin and the control group with metformin for 3 months. Before and after 3 months of treatment, fasting venous blood was collected on the 3rd day of menstruation. Serum testosterone, luteinizing hormone (LHN), follicle stimulating hormone (FSH), fasting insulin (FINSN), fasting blood glucose (FPG), and Chinese medicine syndrome (TCM) were measured. Results there were significant differences between the two groups in menstrual abnormality, acne, the total integral of TCM syndromes, the volume of ovary and the number of follicles. After treatment, the total score of acne and TCM syndromes were statistically different (P0.05N), the abnormal menstruation score, ovarian volume, follicle number had no statistical difference (P0.05G). The total effective rate of acupuncture and medicine group was 83.33, the total effective rate of western medicine group was 63.33, the difference was statistically significant (P 0.05). There was a significant difference in T value between the two groups before and after treatment (P 0.01), and there was a significant difference between the two groups after treatment (P 0.05). After treatment, the LHH / FSH value of the two groups was significantly lower than that of the pre-treatment group (P 0.01), and there was no significant difference between the two groups before and after treatment (P 0.05). There were significant differences in fins between acupuncture and medicine group before and after treatment (P 0.05), in western medicine group (fins), there was significant difference between the two groups before and after direct treatment of HOMA-IR (P 0.01), and there was no significant difference between the two groups after FINSX HOMA-IR treatment. Conclusion there is no significant difference between acupuncture and metformin in the treatment of liver depression. Hot puberty PCOS is safe, The effective treatment method can reduce the serum TLHH / FSHH / FSHINSHOMA-IRR, reduce the symptoms of hyperandrogen, ovarian volume and follicle number, and the overall curative effect is better than that of metformin alone.
【學位授予單位】：湖南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R711.75

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