本文選題：復(fù)發(fā)性流產(chǎn) + 凍存淋巴細(xì)胞主動免疫治療�。� 參考：《南京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:研究中藥補(bǔ)腎調(diào)沖法聯(lián)合凍存淋巴細(xì)胞治療同種免疫不足不明原因復(fù)發(fā)性流產(chǎn)患者的臨床療效。方法:246例同種免疫不足不明原因復(fù)發(fā)性流產(chǎn)患者,知情同意原則自愿選擇治療方式,分為治療組(n=86例)、對照組1(n=76例)和對照組2(n=67例),脫落及治療中剔除患者17例。治療組給予中藥補(bǔ)腎調(diào)沖法聯(lián)合凍存淋巴細(xì)胞及黃體支持;對照組1給予中藥補(bǔ)腎調(diào)沖法和黃體支持;對照組2僅給予黃體支持治療。計(jì)算治療組封閉抗體轉(zhuǎn)陽率,通過比較三個組別的婦娠成功率、中醫(yī)癥狀改善療效、早期血HCG及雌二醇升幅水平,以及三個組別的活產(chǎn)率,評價中藥補(bǔ)腎調(diào)沖法聯(lián)合凍存淋巴細(xì)胞治療復(fù)發(fā)性流產(chǎn)患者的臨床療效。結(jié)果:1.治療組86例患者,第一療程轉(zhuǎn)陽率55.8%,第二療程轉(zhuǎn)陽率76.3%,累計(jì)陽率89.5%。2.治療組、對照組1和對照組2妊娠成功率分別為87.2%、78.9%和65.7%。與對照組1和對照組2相比,治療組妊娠成功率顯著增加,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。3.三組妊娠成功患者早期血HCG及E2升幅水平比較,治療組血激素升幅水平優(yōu)于對照組1和對照組2,異具有統(tǒng)計(jì)學(xué)意義(P0.05)。4.三組中醫(yī)單項(xiàng)癥狀療效比較,治療組中醫(yī)癥狀改善優(yōu)于對照組1和對照組2,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。5.隨訪已產(chǎn)婦,計(jì)算活產(chǎn)率,三組活產(chǎn)率別為80.3%、64.8%和46.7%,三組相比差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:中藥補(bǔ)腎調(diào)沖法聯(lián)合凍存淋巴細(xì)胞治療同種免疫不足不明原因復(fù)發(fā)性流產(chǎn)可明顯提高治療妊娠率,活產(chǎn)率高,未見明顯不良反應(yīng),母兒安全性良好。
[Abstract]:Objective: to study the clinical effect of tonifying kidney and regulating chong method combined with cryopreserved lymphocytes in the treatment of recurrent abortion of unknown cause of alloimmune deficiency. Methods two hundred and six cases of recurrent abortion with unknown cause of alloimmune deficiency were randomly divided into two groups: treatment group (86 cases), control group (1(n=76) and control group (2(n=67). 17 cases were excluded from the treatment. The treatment group was treated with tonifying kidney and tonifying the kidney combined with cryopreserved lymphocyte and luteal body support; the control group 1 was treated with tonifying kidney and regulating luteal body support; the control group only received luteal support therapy. The positive rate of blocking antibody in the treatment group was calculated. By comparing the success rate of pregnant women in three groups, the curative effect of TCM symptom improvement, the levels of serum HCG and estradiol in early stage, and the live birth rate of the three groups, Objective: to evaluate the clinical effect of tonifying kidney and tonifying the kidney combined with cryopreserved lymphocytes in the treatment of recurrent abortion. The result is 1: 1. In the treatment group, 86 patients, the first course of treatment turned positive rate 55.8, the second course of treatment turned positive rate 76.3um, the cumulative positive rate 89.5. The success rate of pregnancy in treatment group, control group 1 and control group 2 was 87.2% and 65.7%, respectively. Compared with control group 1 and control group 2, the success rate of pregnancy in treatment group was significantly increased, and the difference was statistically significant (P 0.05. 3). The serum levels of HCG and E2 were higher in the treatment group than in the control group 1 and 2, respectively, and the difference was statistically significant (P 0.05. 4). The improvement of TCM symptoms in the treatment group was better than that in the control group (1) and the control group (2). The difference was statistically significant (P 0.05). The live birth rate of the three groups was 80.3% and 46.7%, respectively. The difference between the three groups was statistically significant (P 0.05). Conclusion: the combined therapy of tonifying kidney and tonifying the kidney combined with cryopreserved lymphocytes in the treatment of recurrent abortion of unknown cause of alloimmune deficiency can obviously improve the rate of pregnancy, live birth rate, no obvious adverse reaction, and good safety of mother and infant.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R714.21

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