本文選題：孕婦 + 改良Ferriman-Gallwey評分�。� 參考：《中山大學(xué)學(xué)報(醫(yī)學(xué)科學(xué)版)》2017年05期

【摘要】：【目的】通過改良(mFG)評分系統(tǒng)評價婦女妊娠期間身體不同部位新生體毛的生長狀況;分析不同部位的多毛評分對診斷多毛的價值,對mFG評分系統(tǒng)進(jìn)行優(yōu)化。【方法】收集自2014年7月至10月在中山大學(xué)孫逸仙紀(jì)念醫(yī)院進(jìn)行產(chǎn)前檢查的孕婦43例,于孕前、孕5~9、10~14、15~20和21~24周進(jìn)行隨訪,并再納入15~24周的72例孕婦進(jìn)行觀察。所有孕婦在每次觀察時均采用mFG評分系統(tǒng)進(jìn)行多毛評分,同時采用高效液相色譜串聯(lián)質(zhì)譜(LC-MS/MS)法檢測血清總睪酮水平。比較不同孕周睪酮水平及mFG分值,總體間的比較采用單因素方差分析法,兩兩比較采用LSD法。作受試者工作特征曲線(ROC)分析各個部位的終毛生長對多毛癥的診斷效能,同時通過Logistics回歸分析出對多毛診斷有顯著性意義的部位。再將這些部位組合、分值相加命名為簡化FG評分(s FG),ROC曲線評估s FG評分系統(tǒng)對多毛診斷的敏感性和特異性,獲得診斷界值。【結(jié)果】在43例從孕前隨訪到中孕的孕婦中,孕前的總睪酮為(1.09±0.59)nmol/L,在孕5~9、10~14和15~20周分別為(1.13±0.40)、(1.28±0.38)、(1.83±0.63)和(1.82±0.52)nmol/L,各組與孕前總睪酮相比,差異有統(tǒng)計學(xué)意義(P0.05)。9個部位的多毛評分中,mFG總分在各組中分別為:1.65±0.60、2.30±0.45、3.60±0.68、4.20±0.41和4.40±0.77。身體不同部位新生終毛出現(xiàn)的先后順序依次為:上腹部、下腹部、下背部、上唇、大腿、上背、胸部、上臂和下頜。納入15~24周觀察的72例孕婦、共115例孕婦中,ROC曲線分析顯示,各個部位對多毛(mFG≥5)診斷的價值由高到低依次為,上唇下背大腿下腹上臂上背胸/上腹下頜。而排在前4位的部位,即上唇、下背、大腿和下腹對多毛診斷的貢獻(xiàn)度最為顯著,其ROC曲線下面積分別為0.779、0.728、0.675和0.626。進(jìn)一步Logistics回歸分析也顯示,對診斷多毛最有價值的部位是上唇、下背、大腿和下腹部。將這4個部位組合診斷多毛,以3為診斷界值時診斷的敏感性和特異性最佳�！窘Y(jié)論】孕24周前,孕婦的mFG評分隨著妊娠的進(jìn)展逐步增加。上唇、下背、大腿和下腹是對多毛診斷有顯著意義的部位,有可能作為代替mFG評分的簡化組合,用以診斷多毛;診斷界值為sFG≥3分。
[Abstract]:[objective] to evaluate the growth status of newborn hair in different parts of the body of women during pregnancy by modified mFG scoring system, and to analyze the value of hairy score of different parts in the diagnosis of hirsutism. The mFG scoring system was optimized. [methods] Forty-three pregnant women who underwent prenatal examination in Sun Yat-sen Memorial Hospital, Sun Yat-sen Memorial University, Sun Yat-sen University, from July to October 2014, were followed up for 24 weeks before pregnancy. 72 pregnant women of 15 ~ 24 weeks were observed. All pregnant women were evaluated with mFG scoring system and serum total testosterone was measured by HPLC tandem mass spectrometry (HPLC / MS / MS). The testosterone levels and mFG scores in different gestational weeks were compared. Univariate analysis of variance and LSD method were used to compare the population. The diagnostic efficacy of terminal hair growth on hypertrichoresis was analyzed by using the operating characteristic curve of the subjects. At the same time, Logistics regression analysis was used to identify the parts with significant significance in the diagnosis of hirsutism. Then the combination of these sites was added as simplified FG score / s FGG / ROC curve to evaluate the sensitivity and specificity of the s FG scoring system for the diagnosis of hirsutism. [results] among 43 pregnant women who were followed up from pre-pregnancy to middle pregnancy, The total testosterone before pregnancy was 1.09 鹵0.59nmol / L, 1.13 鹵0.40nmol / L and 1.82 鹵0.52nmol / L, respectively, at the week of 5 weeks (1.13 鹵0.40) and 1.82 鹵0.52 (nmol / L), respectively. The total score of MFG in 9 parts of the pregnancy group was 1.65 鹵0.602.30 鹵0.453.60 鹵0.684.20 鹵0.684.20 鹵0.41 and 4.40 鹵0.777.The results showed that there was no significant difference between the two groups in total testosterone before pregnancy (1.09 鹵0.59 nmol / L), and the total score of mFG was 1.65 鹵0.602.30 鹵0.453.60 鹵0.684.60 鹵0.684.20 鹵0.41 and 4.40 鹵0.77 respectively. The order of appearance of new hair in different parts of body is upper abdomen, lower back, upper lip, thigh, upper back, chest, upper arm and mandible. The ROC curve analysis of 115 cases of 72 pregnant women who were observed 24 weeks after 15 weeks showed that the value of each part in diagnosis of hyperhirhidrosis MFG 鈮，

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