本文選題：地諾前列酮栓 + 縮宮素　； 參考：《南方醫(yī)科大學學報》2017年01期

【摘要】：目的大樣本分析廣東省珠三角地區(qū)5年中地諾前列酮栓用于孕晚期引產(chǎn)的臨床療效和安全性。方法將廣東省珠三角地區(qū)使用地諾前列酮栓進行孕晚期引產(chǎn)的20家醫(yī)院按醫(yī)院級別分層,省級醫(yī)院和市區(qū)級醫(yī)院各選取三家醫(yī)院作為研究單位。按照嚴格的納入標準和剔除標準篩選出6家醫(yī)院2010年1月~2014年12月1390例地諾前列酮栓引產(chǎn)病例作為研究組,并抽取同期957例單純使用縮宮素引產(chǎn)病例作為對照組,回顧性分析地諾前列酮栓的臨床療效及安全性。結(jié)果地諾前列酮栓組的第1產(chǎn)程潛伏期時長為4.06±2.65 h,長于縮宮素組3.20±2.08 h,2組相比結(jié)果有統(tǒng)計學意義[P=0.003,95%CI(0.182,0.920)],地諾前列酮栓組活躍期及第2產(chǎn)程時長為1.73±1.32 h/0.49±0.37 h,短于縮宮素組2.22±1.75 h/0.54±0.43 h,兩組相比結(jié)果有統(tǒng)計學意義[P=0.000,95%CI(-0.795,-0.363)/P=0.003,95%CI(-0.137,-0.028)],兩組相比第1產(chǎn)程及總產(chǎn)程無統(tǒng)計學差異;兩組經(jīng)陰道分娩率無統(tǒng)計學差異;母嬰不良反應發(fā)生率無統(tǒng)計學差異。結(jié)論孕晚期地諾前列酮栓引產(chǎn)的安全性與縮宮素相似,臨床療效優(yōu)于縮宮素,是一種安全有效的引產(chǎn)方法。
[Abstract]:Objective to analyze the clinical efficacy and safety of 5-year Diloprostone suppository in late pregnancy induced labor in Pearl River Delta area of Guangdong Province. Methods Twenty hospitals in the Pearl River Delta area of Guangdong province were divided into hospital levels and three hospitals were selected as the research units for the induction of labor in the late pregnancy stage. The provincial hospitals and the urban hospitals respectively were selected as the research units. According to strict inclusion criteria and exclusion criteria, 1390 cases of induced labor induced by denoprostone suppository were selected from 6 hospitals from January 2010 to December 2014 as study group, and 957 cases of labor induced by oxytocin were selected as control group during the same period. The clinical efficacy and safety of dinoprostone suppository were analyzed retrospectively. Results the latency of the first stage of labor was 4.06 鹵2.65 hours in the desitroprostone suppository group, which was significantly longer than that in the oxytocin group (3.20 鹵2.08 h) [P < 0.003]. The active period and the second stage of labor were 1.73 鹵1.32 h / 0.49 鹵0.37 h, and 2.22 鹵1.75 h respectively in the desnoprostone suppository group (P < 0.003), and the duration of the second stage of labor was 1.73 鹵1.32 h / 0.49 鹵0.37 h in the denoprostone suppository group, which was significantly longer than that in the oxytocin group (3.20 鹵2.08 h). H / r 0.54 鹵0.43 h, the results of the two groups were statistically significant (P < 0.000 ~ 95). There was no significant difference between the two groups in the first stage of labor and the total stage of labor. There was no significant difference in the rate of vaginal delivery between the two groups, and there was no significant difference in the incidence of adverse reactions between mother and infant. Conclusion the safety of diloprostone suppository is similar to oxytocin, and the clinical efficacy is better than oxytocin. It is a safe and effective method for induced labor.
【作者單位】： 南方醫(yī)科大學南方醫(yī)院婦產(chǎn)科;順德第一人民醫(yī)院婦產(chǎn)科;番禺何賢紀念醫(yī)院婦產(chǎn)科;番禺中心醫(yī)院婦產(chǎn)科;廣州醫(yī)科大學附屬第三醫(yī)院婦產(chǎn)科;中山大學孫逸仙紀念醫(yī)院婦產(chǎn)科;
【基金】：廣東省高等教育“創(chuàng)新強校工程”專項資金
【分類號】：R719.3

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