本文選題：多囊卵巢綜合征 + 肥胖�。� 參考：《中國現(xiàn)代醫(yī)學(xué)雜志》2015年18期

【摘要】：目的探討多囊卵巢綜合征(PCOS)患者胰島素抵抗(IR)、糖代謝異常與體重指數(shù)(BMI)的關(guān)系。方法90例PCOS患者按BMI分為非肥胖組50例和肥胖組40例,比較兩組患者BMI、腰臀比、口服葡萄糖耐量(OGTT)及胰島素釋放、穩(wěn)態(tài)模式胰島素抵抗指數(shù)(HOMA-IR)、β細胞功能指數(shù)(HOMA-B)、空腹胰島素敏感指數(shù)(ISI)水平的差異。結(jié)果 1PCOS肥胖組患者BMI、腰圍、臀圍及腰臀比均顯著高于非肥胖PCOS患者;2PCOS患者IR發(fā)生率為67.78%。糖代謝異常發(fā)生率為33.33%,其中空腹血糖受損(IFG)的發(fā)生率為15.56%;糖耐量受損(IGT)的發(fā)生率為10.00%;2型糖尿病(T2DM)的發(fā)生率為7.78%。PCOS肥胖組患者IR、IFG、IGT、T2DM的發(fā)生率顯著高于非肥胖PCOS患者。3PCOS肥胖組患者0 min、30 min、1 h、2 h血糖及胰島素水平均顯著高于非肥胖PCOS患者。4PCOS肥胖組患者HOMA-IR和HOMA-B水平[(5.67±3.86)和(310.82±233.12)]高于非肥胖PCOS患者[(3.88±2.37),P=0.008]和[(194.31±119.90),P=0.003],而ISI水平(0.011±0.006)低于非肥胖PCOS患者[(0.018±0.014),P=0.01)]。結(jié)論肥胖可減低PCOS患者胰島素的敏感性,加重胰島素抵抗(IR),導(dǎo)致高胰島素血癥,促進PCOS患者糖代謝異常的發(fā)生。
[Abstract]:Objective to investigate the relationship between insulin resistance, glucose metabolism and body mass index (BMI) in patients with polycystic ovary syndrome (PCOS). Methods according to BMI, 90 patients with PCOS were divided into non-obese group (n = 50) and obese group (n = 40). BMI, waist-hip ratio, oral glucose tolerance (GTT) and insulin release were compared between the two groups. The levels of homeostasis model insulin resistance index (HOMA-IRI), 尾 cell function index (尾 cell function index) and fasting insulin sensitivity index (ISI) were different. Results the incidence of BMI, waist circumference, hip circumference and waist-to-hip ratio in obese 1PCOS group was significantly higher than that in non-obese PCOS group (67.78%). The incidence of abnormal glucose metabolism was 33.33, in which the incidence of impaired fasting blood glucose (IFG) was 15.56; the incidence of impaired glucose tolerance (IGT) was 10.00 type 2 diabetes mellitus (T2DM). The incidence of IGT2DM in obese patients with 7.78%.PCOS was significantly higher than that in patients with non-obese PCOS (0.3PCOS). The levels of HOMA-IR and HOMA-B in obese group were significantly higher than those in non-obese PCOS group [5.67 鹵3.86 and 310.82 鹵233.12], respectively, and were significantly higher in obese group than in non-obese PCOS patients [3.88 鹵2.37 P0. 008] and [194.31 鹵119.90 P0. 003], while ISI level was 0.011 鹵0. 006, which was lower than that in non obese PCOS patients (0. 018 鹵0. 014, P 0. 01). Conclusion Obesity can reduce insulin sensitivity in PCOS patients, aggravate insulin resistance, lead to hyperinsulinemia and promote abnormal glucose metabolism in PCOS patients.
【作者單位】： 蘭州大學(xué)第一醫(yī)院內(nèi)分泌科;
【分類號】：R711.75

【參考文獻】

相關(guān)期刊論文 前1條

1 高芳芳;劉戈力;鄭榮秀;姜麗紅;鮑鵬麗;;肥胖幼鼠脂肪組織vaspin與胰島素敏感性的關(guān)系[J];中國當代兒科雜志;2013年01期

【共引文獻】

相關(guān)期刊論文 前10條

1 張多加;吳效科;;多囊卵巢綜合征的發(fā)育學(xué)起源[J];國際婦產(chǎn)科學(xué)雜志;2013年05期

2 余仁強;吳小優(yōu);周詳;朱靜;馬路一;;矢車菊素-3-葡萄糖苷對肥胖大鼠體重、血脂及胰島素抵抗的影響[J];中國當代兒科雜志;2014年05期

3 王菲;;培哚普利聯(lián)合吲達帕胺治療鹽敏感性高血壓的臨床研究[J];現(xiàn)代藥物與臨床;2014年06期

4 印存思;潘維君;高超;崔毓桂;;胰島素受體基因酪氨酸激酶區(qū)單核苷酸多態(tài)性與多囊卵巢綜合征的相關(guān)性[J];重慶醫(yī)學(xué);2014年16期

5 張建偉;;二甲雙胍聯(lián)合激素治療多囊卵巢綜合征的近期以及遠期療效觀察[J];安徽醫(yī)藥;2014年07期

6 張?zhí)硭?鄒先翔;蘇淑軍;李田;萬t，

本文編號：1919433