本文選題：宮頸癌 + 神經(jīng)纖維�。� 參考：《中國(guó)實(shí)用婦科與產(chǎn)科雜志》2015年05期

【摘要】：目的探討宮頸癌灶精細(xì)組織結(jié)構(gòu),了解宮頸癌灶的組織成分。方法選取2014年6-10月在南方醫(yī)科大學(xué)南方醫(yī)院行宮頸活檢及廣泛性子宮切除術(shù)后的新鮮宮頸癌灶標(biāo)本33例,分別采用HE染色、特殊染色及多種免疫組織化學(xué)染色對(duì)宮頸癌灶進(jìn)行定性研究。結(jié)果 (1)宮頸癌灶中除各種不同分化程度的癌細(xì)胞外,還含有豐富的纖維結(jié)締組織,包括膠原纖維及彈力纖維,未見(jiàn)平滑肌纖維;含有大量的血管,包塊微小動(dòng)靜脈及微血管;淋巴管含量較多,未見(jiàn)淋巴結(jié);部分血管及淋巴管腔內(nèi)見(jiàn)癌細(xì)胞浸潤(rùn)。(2)除上述基本結(jié)構(gòu)外,發(fā)現(xiàn)部分宮頸癌灶中存在神經(jīng)纖維。特異性標(biāo)記神經(jīng)纖維的S-100抗體染色陽(yáng)性有14例,陽(yáng)性比例為42.42%;特異性標(biāo)記交感神經(jīng)的TH抗體染色陽(yáng)性數(shù)有7例,標(biāo)記副交感神經(jīng)的VIP抗體染色陽(yáng)性數(shù)有5例,兩者與S-100陽(yáng)性數(shù)比例分別為50%、35.71%;特異性標(biāo)記新生神經(jīng)的GAP-43抗體染色陽(yáng)性有11例,其與S-100陽(yáng)性數(shù)比例為78.57%。結(jié)論宮頸癌灶中除癌細(xì)胞、纖維結(jié)締組織、血管及淋巴管等基本組織結(jié)構(gòu)外,還存在神經(jīng)纖維,且大部分神經(jīng)為新生神經(jīng),交感神經(jīng)略高于副交感神經(jīng)。
[Abstract]:Objective to investigate the fine tissue structure of cervical cancer focus and understand the tissue composition of cervical cancer focus. Methods Thirty-three specimens of cervical cancer from June to October 2014 were collected from cervical biopsy and extensive hysterectomy in Southern Hospital of Southern Medical University of Southern China. The specimens were stained with HE, respectively. Special staining and immunohistochemical staining were used to study the cervical cancer foci qualitatively. Results (1) there were abundant fibrous connective tissue, including collagen fiber and elastic fiber, no smooth muscle fiber, a large number of blood vessels, small arteriovenous masses and microvessels in cervical cancer foci, in addition to cancer cells with different differentiation degrees. In addition to the above basic structure, nerve fibers were found in some cervical cancer foci. S-100 antibody staining was positive in 14 cases (42.422%), th antibody staining was positive in 7 cases and VIP antibody staining in parasympathetic nerve was 5 cases. The positive ratio of S-100 to S-100 was 35.71, and the positive rate of GAP-43 antibody to S-100 was 78.57 in 11 cases. Conclusion besides the basic tissue structures such as cancer cells, fibrous connective tissues, blood vessels and lymphatic vessels, there are also nerve fibers in cervical cancer focus. Most of the nerves are neonate, and the sympathetic nerve is slightly higher than the parasympathetic nerve.
【作者單位】： 南方醫(yī)科大學(xué)南方醫(yī)院婦產(chǎn)科;南方醫(yī)科大學(xué)南方醫(yī)院病理科;
【基金】：國(guó)家自然科學(xué)基金(81272585) 廣東省科技計(jì)劃項(xiàng)目(2012B031800392) 南方醫(yī)科大學(xué)南方醫(yī)院高層次匹配課題(201305)
【分類(lèi)號(hào)】：R737.33

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