在反復(fù)種植失敗患者中應(yīng)用宮腔鏡檢查及宮腔搔刮術(shù)的臨床意義
本文選題:反復(fù)種植失敗 + 宮腔鏡; 參考:《安徽醫(yī)科大學(xué)學(xué)報(bào)》2017年08期
【摘要】:目的探討宮腔鏡檢查及宮腔搔刮術(shù)在反復(fù)種植失敗患者中應(yīng)用的臨床意義。方法選擇反復(fù)種植失敗的不孕患者205例,根據(jù)是否行宮腔鏡檢查和宮腔搔刮術(shù)分為3組:A組:行宮腔鏡檢查聯(lián)合宮腔搔刮術(shù)(n=101);B組:單純行宮腔搔刮術(shù)(n=39);C組:未予任何干預(yù)措施(n=65)。將A組按照檢查情況分為宮腔形態(tài)正常組(A1組)和宮腔形態(tài)異常組(A2組),分析A組宮腔鏡檢查情況,并比較4組患者再次移植周期的臨床妊娠率、胚胎種植率及不良妊娠率。結(jié)果 A組57.4%宮腔形態(tài)正常(A1),42.6%顯示宮腔內(nèi)微小病變(A2),包括子宮內(nèi)膜炎、子宮內(nèi)膜息肉及增生、宮腔黏連等。A1組、A2組及B組臨床妊娠率與胚胎種植率均明顯高于C組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),但A1、A2及B組間比較無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論宮腔鏡能顯示子宮腔內(nèi)微小病變,宮腔鏡檢查聯(lián)合宮腔搔刮術(shù)和單純搔刮術(shù)均有助于提高反復(fù)種植失敗患者的臨床妊娠率,但前者與后者相比并未提高臨床妊娠率。
[Abstract]:Objective to investigate the clinical significance of hysteroscopy and curettage in patients with recurrent implant failure. Methods 205 infertile patients who failed to implant repeatedly were divided into 3 groups according to whether or not hysteroscopy and uterine cavity curettage were performed: group A: group B: group C: no intervention measures were given. Group A was divided into normal uterine cavity shape group (A 1 group) and abnormal uterine cavity shape group (A 2 group) according to the examination. The hysteroscopy examination of group A was analyzed, and the clinical pregnancy rate, embryo implantation rate and adverse pregnancy rate of 4 groups were compared. Results the clinical pregnancy rate and embryo implantation rate were significantly higher in group A (57.4%) than that in group C (42.6%), including endometritis, endometrial polyps and hyperplasia, uterine cavity adhesion, and so on. The clinical pregnancy rate and embryo implantation rate in group A 1 were significantly higher than those in group C, and the clinical pregnancy rate and embryo implantation rate in group A 1 were significantly higher than those in group C. The difference was statistically significant (P 0.05), but there was no significant difference between group A 1 A 2 and group B. Conclusion hysteroscopy can show minimal changes in uterine cavity. Hysteroscopy combined with intrauterine curettage and simple curettage can improve the clinical pregnancy rate of patients with repeated implantation failure, but the former has not increased the clinical pregnancy rate compared with the latter.
【作者單位】: 安徽醫(yī)科大學(xué)第一附屬醫(yī)院生殖中心;
【基金】:衛(wèi)生部公益性行業(yè)科研專項(xiàng)(編號(hào):201402004) 國(guó)家自然科學(xué)基金青年基金項(xiàng)目(編號(hào):81501232)
【分類(lèi)號(hào)】:R714.8
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